4,7-Dihydroxyoctanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 4,7-Dihydroxyoctanoic acid
• 英文别名: 4,7-dihydroxyoctanoic acid
• 化学式: C₈H₁₆O₄
• 分子量: 176.21
• InChiKey: AWGJZHDUIWLGAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• MEDICAL MATERIAL MADE OF TITANIUM FIBER
  申请人：Kuboki, Yoshinori

  公开号：EP1552855A1

  公开（公告）日：2005-07-13

  It is intended to provide a scaffold whereby a bone and a metallic material can three dimensionally form together a stereoscopic binding layer. Thus, a geometric space sufficient for cell actions is provided. As a result, the time required for the formation of a stereoscopic bond can be shortened and, moreover, a bond can be self-repaired owning to cell actions even in the case where a pair of the bond is injured by a wound, etc. As a material for designing a scaffold, titanium fibers of less than 100 µm in size and having an aspect ratio of 20 or more are selected. Then these fibers are entangled together to form a layer which is integrally fixed by vacuum sintering to a periphery surface of the various implant bodies, and coated with apatite. The fact that the layer contains spaces of an excellent ability to induce a biological hard tissue and fix the same is proved by the material, in which the layer is fixed to the periphery of an implant.

  其目的是提供一种支架，使骨骼和金属材料能够在三维空间内共同形成一个立体结合层。这样，就为细胞的活动提供了足够的几何空间。因此，形成立体结合层所需的时间可以缩短，此外，即使结合层的一对因伤口等原因而受伤，结合层也可以在细胞作用下自我修复。作为设计支架的材料，钛纤维的尺寸小于 100 微米，长宽比大于等于 20。然后将这些纤维缠绕在一起形成一层，通过真空烧结整体固定在各种植入体的外围表面，并涂上磷灰石。该层包含的空间具有诱导生物硬组织和固定生物硬组织的出色能力，这一点已通过将该层固定在植入体外围的材料得到证实。
• Medical material made of titianium fiber
  申请人：Kuboki Yoshinori

  公开号：US20060073181A1

  公开（公告）日：2006-04-06

  It is intended to provide a scaffold whereby a bone and a metallic material can three dimensionally form together a stereoscopic binding layer. Thus, a geometric space sufficient for cell actions is provided. As a result, the time required for the formation of a stereoscopic bond can be shortened and, moreover, a bond can be self-repaired owning to cell actions even in the case where a pair of the bond is injured by a wound, etc. As a material for designing a scaffold, titanium fibers of less than 100 μm in size and having an aspect ratio of 20 or more are selected. Then these fibers are entangled together to form a layer which is integrally fixed by vacuum sintering to a periphery surface of the various implant bodies, and coated with apatite. The fact that the layer contains spaces of an excellent ability to induce a biological hard tissue and fix the same is proved by the material, in which the layer is fixed to the periphery of an implant.

  其目的是提供一种支架，使骨骼和金属材料能够三维地共同形成一个立体结合层。这样，就为细胞的活动提供了足够的几何空间。因此，形成立体结合层所需的时间可以缩短，此外，即使结合层的一对因伤口等原因而受伤，结合层也可以在细胞作用下自我修复。作为设计支架的材料，钛纤维的尺寸小于 100 μm，长宽比大于等于 20。然后将这些纤维缠绕在一起形成一层，通过真空烧结整体固定在各种植入体的外围表面，并涂上磷灰石。该层包含的空间具有诱导生物硬组织和固定生物硬组织的出色能力，这一点已通过将该层固定在植入体外围的材料得到证实。
• US7419679B2
  申请人：——

  公开号：US7419679B2

  公开（公告）日：2008-09-02