phenylalanyl=>phenylalanyl=>phenylalanine | 2578-81-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: phenylalanyl=>phenylalanyl=>phenylalanine
• 英文别名: Phenylalanyl=>phenylalanyl=>phenylalanin；DL-Phenylalanyl-DL-phenylalanyl-DL-phenylalanin；2-[[2-[(2-amino-3-phenylpropanoyl)amino]-3-phenylpropanoyl]amino]-3-phenylpropanoic acid
• CAS: 2578-81-6
• 化学式: C₂₇H₂₉N₃O₄
• 分子量: 459.545
• InChiKey: CBENHWCORLVGEQ-UHFFFAOYSA-N

物化性质

• 沸点：
  788.8±60.0 °C(Predicted)
• 密度：
  1.240±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 钯 、 溶剂黄146 作用下， 生成 phenylalanyl=>phenylalanyl=>phenylalanine
  参考文献：
  名称：

  �ber die Synthese von Peptiden desdl-Phenylalanins

  摘要：

  DOI：

  10.1007/bf00902822

文献信息

• Biomimetic protecting-group-free 2′, 3′-selective aminoacylation of nucleosides and nucleotides
  作者：Sohyoung Her、Ronald Kluger

  DOI：10.1039/c0ob00795a

  日期：——

  Aminoacyl phosphate monoesters can be prepared free of an amino-protecting group and used directly in lanthanum-promoted selective monoacylation of either the 2′ or 3′-hydroxyl of nucleosides and nucleotides. For example, phenylalanyl ethyl phosphate rapidly forms esters with either of the 2′ or 3′-hydroxyls of ribonucleosides and nucleotides in the presence of lanthanum ions in aqueous buffer. Oligomerization

  可以制备不含氨基保护基的氨基酰基磷酸单酯，并将其直接用于镧促进的核苷和核苷酸的2'或3'-羟基选择性单酰基化。例如，在水缓冲液中存在镧离子的情况下，磷酸苯丙氨酰基乙基磷酸酯与核糖核苷的2'或3'-羟基和核苷酸迅速形成酯。氨酰基磷酸的低聚比酯的形成慢得多，并且不是竞争性的过程。试剂的竞争性水解缓慢。通过扩展，该途径应提供简化的通向tRNA的合成氨基酰化衍生物的一般途径。
• Novel spergualin-related compounds and process for producing the same
  申请人：MICROBIAL CHEMISTRY RESEARCH FOUNDATION

  公开号：EP0241797A2

  公开（公告）日：1987-10-21

  The present invention relates to novel Spergualin-related compounds represented by the general formula [I] R2 is a residue obtained by removing, from an amino acid or peptide, the hydroxyl group of the carboxyl group and, when R, is a group other than -H, R2 is same as R, , or a pharmacologically acceptable salt thereof. Said compounds or salts thereof have an immune-modulating action. The invention further relates to pharmaceutical formulations having an immuno-modulating activity which contain such Spergualin-related compounds and a process for the manufacture of these compounds and preparations.

  本发明涉及由通式[I]表示的新型 Spergualin 相关化合物 R2 是通过从氨基酸或肽中去除羧基的羟基而得到的残基，当 R 是除-H 以外的基团时，R2 与 R 相同，或其药理上可接受的盐。上述化合物或其盐具有免疫调节作用。 本发明还涉及具有免疫调节活性的药物制剂，其中含有此类与 Spergualin 相关的化合物，以及制造这些化合物和制剂的工艺。
• Novel spergualin-related compounds and preparation and application of the same
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0347820A1

  公开（公告）日：1989-12-27

  The present invention relates to novel spergualin-related compounds represented by the general formula [I]: wherein X is -(CH₂)₁-₅ OR Y is a hydrogen atom or a residue obtained by removing a hydroxyl group from the carboxyl group of an amino acid or a peptide; m is 0, 1 or 2 and n is 1 or 2, with the proviso that Y is not a hydrogen atom when n is 2 and m is 0. This compounds are stable and exhibit a high immunosuppressive activity.

  本发明涉及由通式[I]表示的新型精蛋白相关化合物： 其中 X 是-(CH₂)₁-₅ OR Y 是氢原子或通过从氨基酸或肽的羧基上去除羟基而得到的残基；m 是 0、1 或 2，n 是 1 或 2，但当 n 是 2 且 m 是 0 时，Y 不是氢原子。 这种化合物性质稳定，具有很高的免疫抑制活性。
• MEDICINAL COMPOSITIONS FOR TREATING IMMUNODEFICIENCY DISEASES
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP1038533A1

  公开（公告）日：2000-09-27

  Spergualin-related compounds such as 15-deoxyspergualin and pharmacologically acceptable salts thereof possess an activity of suppressing the function of monocyte or macrophage are useful as drugs for the treatment of immunodeficiency accompanied by a reduced CD4+ T cell level as observed in HIV infection.

  具有抑制单核细胞或巨噬细胞功能活性的橙皮苷相关化合物，如 15-脱氧橙皮苷及其药理上可接受的盐类，可用作治疗因 CD4+ T 细胞水平降低而导致的免疫缺陷（如在艾滋病毒感染中观察到的情况）的药物。
• US4956504A
  申请人：——

  公开号：US4956504A

  公开（公告）日：1990-09-11