2-(Butan-2-yl)-2-hydroxybutanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2-(Butan-2-yl)-2-hydroxybutanedioic acid
• 英文别名: 2-butan-2-yl-2-hydroxybutanedioic acid
• 化学式: C₈H₁₄O₅
• 分子量: 190.19
• InChiKey: DEWAWQLAIJWSRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Isopropylmalate synthase from Nicotiana tabacum and methods and uses thereof
  申请人：Philip Morris Products S.A.

  公开号：EP2565265A1

  公开（公告）日：2013-03-06

  The present invention relates to a mutant, non-naturally occurring or transgenic plant cell comprising: (i) at least one polynucleotide comprising, consisting or consisting essentially of a sequence encoding an isopropylmalate synthase and having at least 60% sequence identity to SEQ ID NO:1 or SEQ ID NO:10 or SEQ ID NO: 12 or SEQ ID NO:14; or (ii) a polypeptide encoded by said polynucleotide(s); or (iii) a polypeptide having at least 60% sequence identity to SEQ ID NO:2 or SEQ ID NO:11 or SEQ ID NO:13 or SEQ ID NO:15; or (iv) a construct, vector or expression vector comprising said polynucleotide sequence(s), optionally wherein said construct, vector or expression vector additionally comprises a promoter comprising, consisting or consisting essentially of the sequence set forth in SEQ ID NO:8 or a variant thereof with at least about 60% identity thereto or a trichome promoter.

  本发明涉及一种突变体、非天然产生的或转基因植物细胞，该细胞包含：(i) 至少一种多核苷酸，该多核苷酸由编码异丙基丙二酸合成酶的序列组成，或主要由编码异丙基丙二酸合成酶的序列组成，并且与SEQ ID NO：1 或 SEQ ID NO:10 或 SEQ ID NO:12 或 SEQ ID NO:14；或 (ii) 由所述多核苷酸编码的多肽；或 (iii) 与 SEQ ID NO：2 或 SEQ ID NO:11 或 SEQ ID NO:13 或 SEQ ID NO:15；或(iv)包含所述多核苷酸序列的构建体、载体或表达载体，可选地，其中所述构建体、载体或表达载体另外包含一个启动子，该启动子由 SEQ ID NO:8 所述序列或其至少约 60% 相同的变体或毛状体启动子组成或基本由其组成。
• ISOPROPYLMALATE SYNTHASE FROM NICOTIANA TABACUM AND METHODS AND USES THEREOF
  申请人：Bakaher Nicholas

  公开号：US20140352706A1

  公开（公告）日：2014-12-04

  The present invention relates to a mutant, non-naturally occurring or transgenic plant cell comprising: (i) at least one polynucleotide comprising, consisting or consisting essentially of a sequence encoding an isopropylmalate synthase and having at least 60% sequence identity to SEQ ID NO:1 or SEQ ID NO:10 or SEQ ID NO: 12 or SEQ ID NO:14; or (ii) a polypeptide encoded by said polynucleotide(s); or (iii) a polypeptide having at least 60% sequence identity to SEQ ID NO:2 or SEQ ID NO:11 or SEQ ID NO:13 or SEQ ID NO:15; or (iv) a construct, vector or expression vector comprising said polynucleotide sequence(s), optionally wherein said construct, vector or expression vector additionally comprises a promoter comprising, consisting or consisting essentially of the sequence set forth in SEQ ID NO:8 or a variant thereof with at least about 60% identity thereto or a trichome promoter.