'Indicin'-N-oxyd | 887923-31-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: 'Indicin'-N-oxyd
• 英文别名: Echinatine, N-oxide；(7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl)methyl 2-hydroxy-2-(1-hydroxyethyl)-3-methylbutanoate
• CAS: 887923-31-1
• 化学式: C₁₅H₂₅NO₆
• 分子量: 315.367
• InChiKey: DNAWGBOKUFFVMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• MANUFACTURE, METHOD AND USE OF ACTIVE SUBSTANCE-RELEASING MEDICAL PRODUCTS FOR PERMANENTLY KEEPING BLOOD VESSELS OPEN
  申请人：Hoffmann Erika

  公开号：US20100063585A1

  公开（公告）日：2010-03-11

  The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings.

  本发明涉及具有优化涂层以释放雷帕霉素的支架和导管球囊，以及制造这些涂层的方法。
• MANUFACTURE, METHOD AND USE OF DRUG-ELUTING MEDICAL DEVICES FOR PERMANENTLY KEEPING BLOOD VESSELS OPEN
  申请人：Hoffmann Erika

  公开号：US20130005758A1

  公开（公告）日：2013-01-03

  The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings.

  本发明涉及具有经过优化的涂层以释放雷帕霉素的支架和导管球囊，以及制造这些涂层的方法。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• BALLOON CATHETER WITH POLYMERIC BALLOON HAVING A SURFACE MODIFIED BY A PHOTOACTIVATION REACTION AND METHOD OF MAKING
  申请人：D'Onofrio Simone

  公开号：US20140378897A1

  公开（公告）日：2014-12-25

  A balloon catheter, in particular a balloon catheter for angioplasty, the balloon having an inner or outer surface modified by means of a photoactivation reaction.

  一个气球导管，特别是用于血管成形术的气球导管，该气球通过光活化反应改性内部或外部表面。
• Expandable medical device for the treatment and prevention of cardiovascular diseases
  申请人：Perelson, Ophir

  公开号：EP1913962A1

  公开（公告）日：2008-04-23

  The invention relates to expandable medical devices such as stents, bioresorbable stents or catheter balloons with or without crimped stents comprising the pharmaceutically active agent gemcitabine as pure compound or incorporated into a drug release matrix optionally in combination with other drugs for the treatment of cardiovascular diseases such as arteriosclerosis, atherosclerosis, stenosis or restenosis and methods for the manufacture of these expandable medical devices.

  本发明涉及用于治疗动脉硬化、动脉粥样硬化、血管狭窄或再狭窄等心血管疾病的可膨胀医疗器械，如支架、生物可吸收支架或带或不带卷边支架的导管球囊，其中包含纯化合物形式的药物活性剂吉西他滨，或将其掺入药物释放基质（可选择与其他药物组合使用），以及制造这些可膨胀医疗器械的方法。