O-acetyl-DL-homoserine | 6232-10-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: O-acetyl-DL-homoserine
• 英文别名: O-acetyl-homoserine；O-Acetyl-DL-homoserin；O-Acetyl-homoserin；O-Acetyl-DL-homoserin；4-(Acetyloxy)-2-azaniumylbutanoate；4-acetyloxy-2-azaniumylbutanoate
• CAS: 6232-10-6
• 化学式: C₆H₁₁NO₄
• 分子量: 161.158
• InChiKey: FCXZBWSIAGGPCB-UHFFFAOYSA-N

物化性质

• 熔点：
  183-185 °C (decomp)
• 沸点：
  327.7±37.0 °C(Predicted)
• 密度：
  1.242±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  DL-高丝氨酸 、 乙酸酐 在 高氯酸 、 溶剂黄146 作用下， 生成 O-acetyl-DL-homoserine
  参考文献：
  名称：

  Diazoacetic Esters of Hydroxyamino Acids¹

  摘要：

  DOI：

  10.1021/ja01525a066

文献信息

• Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms
  申请人：CJ Cheiljedang Corporation

  公开号：US20140296466A1

  公开（公告）日：2014-10-02

  The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.

  本发明涉及一种通过在酸催化剂存在下水解微生物产生的O-酰基同型半胱氨酸，生产基于生物的同型半胱氨酸内酯和基于生物的有机酸的方法。根据本发明，利用微生物产生的O-酰基同型半胱氨酸作为原料，生产1,4-丁二醇、γ-丁内酯、四氢呋喃等工业上非常有用的产品。微生物产生的O-酰基同型半胱氨酸可以替代传统的石化产品，可以解决环境问题，包括污染物排放和自然资源枯竭，并且可以持续可再生，不会耗尽自然资源。
• Use of dimethyl disulfide for methionine production in microoragnisms
  申请人：Zelder Oskar

  公开号：US20090281353A1

  公开（公告）日：2009-11-12

  The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli , can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.

  本发明涉及改进的方法和生物体，用于甲硫氨酸的生产。该发明表明，例如C. glutamicum或E. coli的ΔmetF生物体或ΔmetE AmetH生物体，可以使用甲基硫醚源，例如二甲基二硫化物（DMDS），作为硫和甲基的来源，绕过对甲硫氨酸合成所需的MetH/MetE和MetF活性以及还原硫酸的需要。本专利还描述了数据，暗示MetY（也称为MetZ）是一种将甲基硫醚源，例如DMDS，嵌入到甲硫氨酸中的酶。C. glutamicum的ΔmetF ΔmetB菌株可以使用甲基硫醚源，例如DMDS，作为硫和甲基的来源。此外，通过添加甲基硫醚源，例如DMDS，改进了通过过度产生O-乙酰同型半胱氨酸的工程原核生物的甲硫氨酸产量。
• [EN] BIOLOGICAL FERMENTATION USING DIHYDROXYACETONE AS A SOURCE OF CARBON<br/>[FR] FERMENTATION BIOLOGIQUE UTILISANT DE LA DIHYDROXYACÉTONE COMME SOURCE DE CARBONE
  申请人：KEMBIOTIX LLC

  公开号：WO2017139420A1

  公开（公告）日：2017-08-17

  The present invention relates to the use of hydrocarbons derived from natural gas in the fermentative production of biochemicals including biofuels. More specifically, the present invention provides the method for manufacturing dihydroxyacetone ("DHA") from natural gas, biogas, biomass and CO2 released from industrial plants including electricity-generating plants, steel mills and cement factories and the use of DHA as a source of organic carbon in the fermentative production of biochemicals including biofuels. The present invention comprises three stages. In the first stage of the present invention, syngas and formaldehyde are produced from natural gas, biogas, biomass and CO2 released from industrial plants. In the second stage of the present invention, formaldehyde and syngas are condensed to produce DHA. In the third stage of the present invention, biochemicals including biofuels are produced from DHA using fermentation process involving wild type or genetically modified microbial biocatalysts.

  本发明涉及使用从天然气中提取的碳氢化合物在生物化学品，包括生物燃料的发酵生产中的应用。更具体地说，本发明提供了一种从天然气、沼气、生物质和工业厂房中释放的CO2中制造二羟基丙酮（"DHA"）的方法，以及将DHA作为有机碳源在发酵生产中制造生物化学品，包括生物燃料的应用。本发明包括三个阶段。在本发明的第一阶段中，从天然气、沼气、生物质和工业厂房中释放的 中产生合成气和甲醛。在本发明的第二阶段中，甲醛和合成气被凝结成DHA。在本发明的第三阶段中，使用野生型或基因改造的微生物生物催化剂进行发酵过程，从DHA中生产生物化学品，包括生物燃料。
• Process for the preparation of 3-amino-2-oxo-pyrrolidines, novel intermediates and their use
  申请人：Degussa-Huls Aktiengensellschaft

  公开号：US20010025109A1

  公开（公告）日：2001-09-27

  The present invention relates to a process for the preparation of &ggr;-lactams of the general formula I 1 The invention relates also to novel advantageous intermediates of the general formulae V, IV and II and their salts 2 and their use. The compounds of the general formula I are obtained by cyclising compounds of the general formula II 3 which can be prepared from the intermediate compounds V.

  本发明涉及一种制备一般式I的γ-内酰胺的方法。本发明还涉及一般式V、IV和II的新型优势中间体及其盐和用途。一般式I的化合物是通过环化一般式II的化合物得到的，而一般式II的化合物可以从中间体化合物V制备。
• USEFUL MICROORGANISM AND METHOD FOR PRODUCING SUBSTANCE OF INTEREST
  申请人：GENARIS, INC.

  公开号：US20150197775A1

  公开（公告）日：2015-07-16

  It is an object of the present invention to provide a bacterial strain that can decrease the amount of an intermediate Compound P converted into Metabolite M and efficiently accumulate Compound P in a medium that is not supplemented with Metabolite M or the final product generated from Metabolite M. The present invention provides a prokaryotic organism having all features (a) to (d) as defined in the specification so as to accumulate Compound P by regulating expression level of Enzyme X that converts Compound P as an intermediate metabolite into Metabolite M in a biosynthetic pathway in which Metabolite M indispensable for the growth is produced from a carbon source.

  本发明的目的是提供一种细菌菌株，该菌株能够降低中间产物P转化为代谢物M的数量，并在不添加代谢物M或从代谢物M生成的最终产物的培养基中高效地积累化合物P。本发明提供了一种原核生物，具有规定在生产必需的代谢物M的生物合成途径中将化合物P转化为中间代谢物M的酶X的表达水平，以通过所有在说明书中定义的特征（a）至（d）来积累化合物P。