N-{[2-(pyridin-3-yl)piperidin-1-yl]carbonothioyl}-1,3-benzodioxole-5-carboxamide

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: N-{[2-(pyridin-3-yl)piperidin-1-yl]carbonothioyl}-1,3-benzodioxole-5-carboxamide
• 英文别名: N-(2-pyridin-3-ylpiperidine-1-carbothioyl)-1,3-benzodioxole-5-carboxamide
• 化学式: C₁₉H₁₉N₃O₃S
• 分子量: 369.4
• InChiKey: FCWCKQVKCUJBLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  95.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• BIASED NMDA RECEPTOR MODULATORS AND USES THEREOF
  申请人：EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE

  公开号：US20220016105A1

  公开（公告）日：2022-01-20

  Described herein are compounds that can be capable of modulating an N-methyl-D-aspartate (NMDA) receptor. In some embodiments, the compound(s) can be a biased modulator of an NMDA receptor. In some embodiments, the compound(s) can be a biased allosteric modulator of an NMDA receptor. Also described herein are methods of treating an NMDA-mediated disease by administering one or more of the compounds described herein. In some embodiments, the compounds can be effective to treat a neurobiological or psychiatric disease or disorder.
• [EN] BIASED NMDA RECEPTOR MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE RÉCEPTEURS NMDA POLARISÉS ET LEURS UTILISATIONS
  申请人：EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE

  公开号：WO2020102443A1

  公开（公告）日：2020-05-22

  Described herein are compounds that can be capable of modulating an N-methyl-D- aspartate (NMD A) receptor. In some embodiments, the compound(s) can be a biased modulator of an NMDA receptor. In some embodiments, the compound(s) can be a biased allosteric modulator of an NMDA receptor. Also described herein are methods of treating an NMDA- mediated disease by administering one or more of the compounds described herein. In some embodiments, the compounds can be effective to treat a neurobiological or psychiatric disease or disorder.