Hyoscin-N-oxid | 1219532-34-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Hyoscin-N-oxid
• 英文别名: 3-hydroxy-2-phenyl-propionic acid 9-methyl-9-oxy-3-oxa-9-aza-tricyclo[3.3.1.0^2,4]non-7-yl ester；9-Methyl-9-oxido-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate；(9-methyl-9-oxido-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl) 3-hydroxy-2-phenylpropanoate
• CAS: 1219532-34-9
• 化学式: C₁₇H₂₁NO₅
• 分子量: 319.357
• InChiKey: GSYQNAMOFFWAPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• NOVEL BRONCHODILATING DIAZAHETEROARYLS
  申请人：Johansson Martin

  公开号：US20120040942A1

  公开（公告）日：2012-02-16

  The invention relates to novel compounds having the general formula (I), and which compounds are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma.

  这项发明涉及具有通式（I）的新化合物，这些化合物可用于治疗由支气管痉挛引起的疾病或疾病，例如慢性阻塞性肺疾病（COPD）和哮喘。
• [EN] NOVEL BRONCHODILATING DIAZAHETEROARYLS<br/>[FR] NOUVEAUX DIAZAHÉTÉROARYLES BRONCHODILATATEURS
  申请人：RESPIRATORIUS AB

  公开号：WO2010097410A1

  公开（公告）日：2010-09-02

  The invention relates to novel compounds having the general formula (I), and which compounds are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma.

  这项发明涉及具有通式（I）的新化合物，这些化合物可用于治疗由支气管痉挛引起的疾病或疾病，例如慢性阻塞性肺疾病（COPD）和哮喘。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• [EN] MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE<br/>[FR] COMPOSÉS DE LACTONE MACROCYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ELIXIR MEDICAL CORP

  公开号：WO2009114010A1

  公开（公告）日：2009-09-17

  The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, -OH, -OP(O)Me2, (II), (III), -O-(CH2)n-OH and -O-(CH2)m-O-(CH2)o-CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of (IV) and (V) wherein each M8 is independently a member selected from the group consisting Of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of (VI), (VII) and (VIII); and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.

  本发明提供了一种制药组合物，该组合物包括一种药用可接受的赋形剂和一种式(I)的化合物，其中R1、R2、R3、R5、R6、R8、M1、M2、M3、M4、M5、M6和M7各自独立地选择自H、C1-6烷基、OH和C1-6羟基烷基的群体中的一种；R4、R7和R9各自独立地选择自C1-6烷氧基和OH的群体中的一种；R10选择自H、-OH、-OP(O)Me2、(II)、(III)、-O-(CH2)n-OH和-O-(CH2)m-O-(CH2)o-CH3的群体中的一种，其中下标n和m各自独立地从2到8，下标o从1到6；L1和L4各自独立地选择自(VI)和(VII)的群体中的一种，其中每个M8各自独立地选择自C1-6烷基、OH和C1-6羟基烷基的群体中的一种；L2和L3各自独立地选择自(VI)、(VII)和(VIII)的群体中的一种；以及其盐、水合物、异构体、代谢物、N-氧化物和前药。