NP-000360 | 34425-25-7

• 物质功能分类: 天然产物 - 木脂素
• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素苷
• 英文名称: NP-000360
• 英文别名: Lyoniside；2-[[7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-3-(hydroxymethyl)-6,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl]methoxy]oxane-3,4,5-triol
• CAS: 34425-25-7；62058-46-2
• 化学式: C₂₇H₃₆O₁₂
• 分子量: 552.576
• InChiKey: GWDZRGQRNHELQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  177
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• COMPOSITION FOR BROWNING INHIBITION AND USE OF SAME
  申请人：Suntory Holdings Limited

  公开号：EP3476227A1

  公开（公告）日：2019-05-01

  The present invention relates to a browning-inhibiting composition containing a compound represented by the following formula (1): wherein R21, R22, R23, R24, R26 and R27 each independently represent a hydrogen atom or a substituent, and at least one of R21 or R23 is a hydrogen atom; when R23 represents a hydrogen atom, at least one of R22 or R24 represents a substituent; R25 represents a hydrogen atom, an oxygen atom, or a substituent; R22 and R23, or R23 and R24 may be bonded together to form a ring with an oxygen atom and a carbon atom to which these Rs are bonded; R25 and R26, or R26 and R27 may be bonded together to form a ring structure with carbon atoms to which these Rs are bonded; X represents an oxygen atom or -CH2-; and a dashed line may represent a double bond.

  本发明涉及一种抑制褐变的组合物，其中含有下式（1）所代表的化合物： 其中R21、R22、R23、R24、R26和R27各自独立地代表氢原子或取代基，R21或R23中至少有一个是氢原子；当R23代表氢原子时，R22或R24中至少有一个代表取代基；R25代表氢原子、氧原子或取代基；R22 和 R23，或 R23 和 R24 可键合在一起，形成具有氧原子和碳原子的环，这些 R 与之键合；R25 和 R26，或 R26 和 R27 可键合在一起，形成具有碳原子的环结构，这些 R 与之键合；X 代表氧原子或-CH2-；虚线可代表双键。
• METHODS OF PREVENTING TUMOR METASTASIS, TREATING AND PROGNOSING CANCER AND IDENTIFYING AGENTS WHICH ARE PUTATIVE METASTASIS INHIBITORS
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20150290233A1

  公开（公告）日：2015-10-15

  A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.
• SYNAPTOJANIN-2 INHIBITORS FOR USE IN THE TREATMENT OF CANCER
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20170042857A1

  公开（公告）日：2017-02-16

  Disclosed herein are synaptojanin-2 inhibitors, and novel methods and uses utilizing same for preventing tumor metastasis, treating cancer or inhibiting synaptojanin-2. Compounds disclosed herein include chlorhexidine and pyrvinium, the compound having the formula: and compounds characterized by the general formula: X-L-[(Y)i-(Z)j]-(L-X)k and/or by the general formula: wherein L, X, Y, Z, D, E, i, j and k are as defined herein.
• [EN] METHODS OF PREVENTING TUMOR METASTASIS, TREATING AND PROGNOSING CANCER AND IDENTIFYING AGENTS WHICH ARE PUTATIVE METASTASIS INHIBITORS<br/>[FR] MÉTHODES DE PRÉVENTION D'UNE MÉTASTASE TUMORALE, DE TRAITEMENT ET DE PRONOSTIC DU CANCER, ET D'IDENTIFICATION D'AGENTS SUSCEPTIBLES DE CONSTITUER DES INHIBITEURS DE MÉTASTASE
  申请人：YEDA RES & DEV

  公开号：WO2014083567A2

  公开（公告）日：2014-06-05

  A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.
• [EN] SYNAPTOJANIN-2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE SYNAPTOJANINE-2 ET LEURS UTILISATIONS
  申请人：YEDA RES & DEV

  公开号：WO2015079413A2

  公开（公告）日：2015-06-04

  Disclosed herein are synaptojanin-2 inhibitors, and novel methods and uses utilizing same for preventing tumor metastasis, treating cancer or inhibiting synaptojanin-2. Compounds disclosed herein include chlorhexidine and pyrvinium, the compound having the formula: (I) and compounds characterized by the general formula: X-L-[(Y)i-(Z)j]-(L-X)k and/or by the general formula:(II) wherein L, X, Y, Z, D, E, i, j and k are as defined herein.