(3R,4S)-3-[[4-(beta-D-吡喃葡萄糖基氧基)-3-甲氧基苯基]甲基]-4,5-二氢-4-[(4-羟基-3-甲氧基苯基)甲基]呋喃-2(3H)-酮 | 23202-85-9

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素苷
• 中文名称: (3R,4S)-3-[[4-(beta-D-吡喃葡萄糖基氧基)-3-甲氧基苯基]甲基]-4,5-二氢-4-[(4-羟基-3-甲氧基苯基)甲基]呋喃-2(3H)-酮
• 中文别名: 罗汉松脂苷
• 英文名称: matairesinoside
• 英文别名: (-)-matairesinol 4'-O-glucoside；matairesinol 4'-O-β-D-glucopyranoside；(3R,4R)-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-[[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]oxolan-2-one
• CAS: 23202-85-9
• 化学式: C₂₆H₃₂O₁₁
• 分子量: 520.533
• InChiKey: AAGCATAPYOEULE-LHHMAMHXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  164
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• Phillygenin glucuronic acid derivative as well as preparation method and application thereof
  申请人：Fu Li

  公开号：US10407455B2

  公开（公告）日：2019-09-10

  The present invention provides a novel phillygenin glucuronic acid derivative shown as a general formula (I). wherein, R1=H, R2=CnH2n+1, R3=CnH2n+1 or R1=CnH2n+1, R2=CnH2n+1,R3=H or R1-R2=—CH2—, R3=CnH2n+1; n=1-30. The present invention further relates to a preparation method of the compound, a pharmaceutical composition taking the compound as an active ingredient, as well as application of the compound in the present invention in antiviral diseases.

  本发明提供了一种通式 (I) 所示的新型菲力苷葡萄糖醛酸衍生物。 其中，R1=H，R2=CnH2n+1，R3=CnH2n+1 或 R1=CnH2n+1，R2=CnH2n+1，R3=H 或 R1-R2=-CH2-，R3=CnH2n+1；n=1-30。本发明进一步涉及本发明化合物的制备方法、以本发明化合物为有效成分的药物组合物以及本发明化合物在抗病毒疾病中的应用。
• Crude drug composition for preventing and treating gastrointestinal dyskinetic diseases
  申请人：Pangenomics Co., Ltd.

  公开号：US20030194451A1

  公开（公告）日：2003-10-16

  The present invention is related to a crude drug composition essentially comprising herbs of Sinapis Semen Alba, Ginseng Radix, Zingiberis Rhizoma Siccus, Amomi Fructus, Myristicae Semen, Saussureae Radix, Cyperi Rhizoma, Magnoliae Cortex, Arecae Semen, Crataegi Fructus, Atractylodes Rhizoma Alba, Agastachis Herba, Glycyrrhiza Radix and additionally comprising at least one herb selected from group consisting of Polygonati Rhizoma, Artemisiae Argyi Folium, Forsythiae Fructus, Caryophylli Flos, Raphani Semen, Menthae Herba according to the need for the prevention and treatment of gastrointestinal dyskinetic diseases and methods of using the above crude drug composition and pharmaceutical composition as prokinetic agent.

  本发明涉及一种粗药物组合物，该组合物主要由白头翁、人参、蛇床子、天麻、肉豆蔻、沙参、香附、厚朴、山萸肉、山楂、白术、炙甘草等药材组成、根据预防和治疗胃肠道运动障碍疾病的需要，还包括至少一种选自何首乌、艾叶、连翘、莸、莱菔子、薄荷组成的组的草药，以及使用上述粗药物组合物和药物组合物作为促动力剂的方法。
• Bed sore medicine cream
  申请人：Hu D. Mary

  公开号：US20050201970A1

  公开（公告）日：2005-09-15

  A skin condition relieving medication, which can be directly applied onto a skin condition prone area of a user, is provided for preventing infection and reducing inflammation and swelling, while allowing air to reach the skin condition prone area in order to dry the skin condition and eventually healing the skin condition, wherein the skin condition relieving medication includes a predetermined amount of primary herb mixture including one or more herbs chosen from forsythia, frankincense, myrrh, cuttlefish bone, honeysuckle, turmeric and garden angelica, provided for the treating of the skin conditions, a predetermined amount of catalyst including vitamin E, and a predetermined amount of binding agent, which most suitably is Vaseline containing the primary herb mixture and the catalyst, and binding the primary herb mixture to the skin condition prone area of the user.

  本发明提供了一种可直接涂抹在使用者易患皮肤病部位的皮肤病缓解药物，用于防止感染、消炎和消肿，同时使空气进入易患皮肤病部位，以干燥皮肤病并最终治愈皮肤病，其中，皮肤病缓解药物包括预定量的主要草药混合物，包括选自连翘、乳香、没药、墨鱼骨、金银花、姜黄和当归的一种或多种草药，用于治疗皮肤病；预定量的催化剂，包括维生素 E；以及预定量的草药混合物，包括选自连翘、乳香、没药、墨鱼骨、金银花、姜黄和当归的一种或多种草药，用于治疗皮肤病、乳香、没药、墨鱼骨、金银花、姜黄和当归中的一种或多种草药，用于治疗皮肤病；预定量的催化剂，包括维生素 E；以及预定量的粘合剂，其中最合适的是凡士林，含有主要草药混合物和催化剂，并将主要草药混合物粘合到使用者易患皮肤病的部位。
• TRACHELOSPERMI CAULIS EXTRACT COMPOSITION FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES
  申请人：Shin-il Pharmaceutical Co., Ltd.

  公开号：EP2040726A1

  公开（公告）日：2009-04-01
• COMPOSITION COMPRISING TRACHELOSPERMI CAULIS AND PYROLA JAPONICA EXTRACTS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES
  申请人：Shin-il Pharmaceutical Co., Ltd.

  公开号：EP2124980A1

  公开（公告）日：2009-12-02