ethyl 4-mesyloxy crotonate | 102547-71-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 4-mesyloxy crotonate
• 英文别名: 4-methanesulfonyloxy-trans-crotonic acid ethyl ester；4-Methansulfonyloxy-trans-crotonsaeure-aethylester；ethyl (E)-4-methylsulfonyloxybut-2-enoate
• CAS: 102547-71-7
• 化学式: C₇H₁₂O₅S
• 分子量: 208.235
• InChiKey: UUFRTUDCQNJDSW-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 4-mesyloxy crotonate 、 (4S)-4-tert-butoxy-3,4-dihydro-2H-pyrrole 1-oxide 以 甲苯 为溶剂， 反应 168.0h， 生成 (2R,3R,3aR,4S)-4-tert-Butoxy-2-methanesulfonyloxymethyl-hexahydro-pyrrolo[1,2-b]isoxazole-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Solid-phase access to polyhydroxypyrrolizidines by 1,3-dipolar cycloaddition of (S)-3-alkoxypyrroline N-oxide to maleate and crotonate derivatives

  摘要：

  2,7-Dihydroxyhexahydropyrrolizine-1-carboxylic acid derivatives have been prepared in solid-phase by intermolecular 1,3-dipolar cycloaddition between an immobilised malcate or 4-hydroxycrotonate and an enantiopure 3-alkoxypyrroline N-oxide. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01208-x
• 作为产物：
  描述：

  甲基磺酰氯 、 ethyl trans-4-(4-methoxybenzyloxy)but-2-enoate 在 TEA 作用下， 以 二氯甲烷 为溶剂， 以68%的产率得到ethyl 4-mesyloxy crotonate
  参考文献：
  名称：

  Solid-phase access to polyhydroxypyrrolizidines by 1,3-dipolar cycloaddition of (S)-3-alkoxypyrroline N-oxide to maleate and crotonate derivatives

  摘要：

  2,7-Dihydroxyhexahydropyrrolizine-1-carboxylic acid derivatives have been prepared in solid-phase by intermolecular 1,3-dipolar cycloaddition between an immobilised malcate or 4-hydroxycrotonate and an enantiopure 3-alkoxypyrroline N-oxide. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01208-x

文献信息

• THE PREPARATION AND SOME CLEAVAGE REACTIONS OF ALKYL AND SUBSTITUTED ALKYL METHANESULPHONATES: THE SYNTHESIS OF FLUORIDES, IODIDES, AND THIOCYANATES
  作者：F. L. M. Pattison、J. E. Millington

  DOI：10.1139/v56-099

  日期：1956.6.1

  Representative esters of methanesulphonic acid were synthesized, and cleaved to form the corresponding fluorides, iodides, and thiocyanates. From this work was developed a convenient laboratory procedure for converting alcohols to fluorides.

  合成了具有代表性的甲磺酸酯，并裂解形成相应的氟化物、碘化物和硫氰酸酯。从这项工作中开发了一种方便的实验室程序，用于将醇转化为氟化物。
• Solid-phase access to polyhydroxypyrrolizidines by 1,3-dipolar cycloaddition of (S)-3-alkoxypyrroline N-oxide to maleate and crotonate derivatives
  作者：Federica Pisaneschi、Carmela Della Monica、Franca M Cordero、Alberto Brandi

  DOI：10.1016/s0040-4039(02)01208-x

  日期：2002.8

  2,7-Dihydroxyhexahydropyrrolizine-1-carboxylic acid derivatives have been prepared in solid-phase by intermolecular 1,3-dipolar cycloaddition between an immobilised malcate or 4-hydroxycrotonate and an enantiopure 3-alkoxypyrroline N-oxide. (C) 2002 Elsevier Science Ltd. All rights reserved.