N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]-2-methyl-2-(4-phenylmethoxybutyl)propanediamide | 807622-35-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]-2-methyl-2-(4-phenylmethoxybutyl)propanediamide
• CAS: 807622-35-1
• 化学式: C₃₁H₃₈N₂O₅
• 分子量: 518.653
• InChiKey: HNDLATKASLBKHU-VSGBNLITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  38
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]-2-methyl-2-(4-phenylmethoxybutyl)propanediamide 在 4-二甲氨基吡啶 、 三乙胺 、 对甲苯磺酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以70%的产率得到(4S)-4-phenyl-2-[2-[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]-6-phenylmethoxyhexan-2-yl]-4,5-dihydro-1,3-oxazole
  参考文献：
  名称：

  Insoluble polystyrene-bound bis(oxazoline): batch and continuous-flow heterogeneous enantioselective glyoxylate–ene reaction

  摘要：

  The use of a new, insoluble polymer-bound bis(oxazoline) ligand (IPB-box) for the copper-catalyzed heterogeneous enantioselective glyoxylate-ene reaction is described. Good activity and ee values in the range 85-95% have been obtained during five to seven recycles, either in batch mode or under flow conditions, demonstrating also the recovery and reuse of the whole catalytically active copper complex. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.08.015
• 作为产物：
  描述：

  4-苄氧基-1-丁醇 在 4-二甲氨基吡啶 、 氢氧化钾 、 草酰氯 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 31.0h， 生成 N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]-2-methyl-2-(4-phenylmethoxybutyl)propanediamide
  参考文献：
  名称：

  Insoluble polystyrene-bound bis(oxazoline): batch and continuous-flow heterogeneous enantioselective glyoxylate–ene reaction

  摘要：

  The use of a new, insoluble polymer-bound bis(oxazoline) ligand (IPB-box) for the copper-catalyzed heterogeneous enantioselective glyoxylate-ene reaction is described. Good activity and ee values in the range 85-95% have been obtained during five to seven recycles, either in batch mode or under flow conditions, demonstrating also the recovery and reuse of the whole catalytically active copper complex. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.08.015

文献信息

• Insoluble polystyrene-bound bis(oxazoline): batch and continuous-flow heterogeneous enantioselective glyoxylate–ene reaction
  作者：Alessandro Mandoli、Simonetta Orlandi、Dario Pini、Piero Salvadori

  DOI：10.1016/j.tetasy.2004.08.015

  日期：2004.10

  The use of a new, insoluble polymer-bound bis(oxazoline) ligand (IPB-box) for the copper-catalyzed heterogeneous enantioselective glyoxylate-ene reaction is described. Good activity and ee values in the range 85-95% have been obtained during five to seven recycles, either in batch mode or under flow conditions, demonstrating also the recovery and reuse of the whole catalytically active copper complex. (C) 2004 Elsevier Ltd. All rights reserved.