erythbidin E

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: erythbidin E
• 英文别名: 2-(2,4-dihydroxyphenyl)-6-methoxybenzofuran；4-(6-Methoxy-1-benzofuran-2-yl)benzene-1,3-diol
• 化学式: C₁₅H₁₂O₄
• 分子量: 256.258
• InChiKey: IEGOZSZLLDQQER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  62.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  erythbidin E 、 乙酸酐 在 吡啶 作用下， 以10 mg的产率得到[3-Acetyloxy-4-(6-methoxy-1-benzofuran-2-yl)phenyl] acetate
  参考文献：
  名称：

  New Constituents from the Roots of Erythrina x bidwillii

  摘要：

  Three new compounds, erythbidins C-E (1-3), together with five known compounds 4-8 were isolated from the roots of Erythrina x bidwillii. Their structures were established on the basis of spectroscopic evidence. Among the isolated compounds, erythbidin E (3) showed a potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

  DOI：

  10.3987/com-07-11065
• 作为产物：
  描述：

  2-(2,4-bis(benzyloxy)phenyl)-6-methoxybenzofuran 在 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 以94%的产率得到erythbidin E
  参考文献：
  名称：

  A practicable environmentally benign one-pot synthesis of 2-arylbenzofurans at room temperature

  摘要：

  我们开发出了一种在常温下环保型单锅合成 2-芳基苯并呋喃的方法。其特点是取代水杨醛的正羟基辅助维蒂希反应，然后原位氧化环化。其优点包括：材料易得且无害、反应条件温和（室温、绿色溶剂和单锅方式）、易于操作和总产率高。利用这种方法合成了各种 2-芳基苯并呋喃，包括四种天然产物。

  DOI：

  10.1039/c2gc16181h

文献信息

• A practicable environmentally benign one-pot synthesis of 2-arylbenzofurans at room temperature
  作者：Lian-Yan Liao、Gang Shen、Xue Zhang、Xin-Fang Duan

  DOI：10.1039/c2gc16181h

  日期：——

  An environmentallyfriendly one-pot synthesis of 2-arylbenzofurans under ambient temperature has been developed. It features an ortho-hydroxyl group assisted Wittig reaction of substituted salicylaldehyde followed by an in situ oxidative cyclization. Its advantages include readily available and non-hazardous materials, benign reaction conditions (room temperature, green solvent and one-pot manner), easy work-up and high overall yields. Utilizing this methodology, various 2-aryl-benzofurans including four natural products have been synthesized.

  我们开发出了一种在常温下环保型单锅合成 2-芳基苯并呋喃的方法。其特点是取代水杨醛的正羟基辅助维蒂希反应，然后原位氧化环化。其优点包括：材料易得且无害、反应条件温和（室温、绿色溶剂和单锅方式）、易于操作和总产率高。利用这种方法合成了各种 2-芳基苯并呋喃，包括四种天然产物。
• New Constituents from the Roots of Erythrina x bidwillii
  作者：Hitoshi Tanaka、Hisanori Hattori、Masaru Sato、Ryozo Yamaguchi、Toshio Fukai、Toshihiro Tanaka、Eiji Sakai

  DOI：10.3987/com-07-11065

  日期：——

  Three new compounds, erythbidins C-E (1-3), together with five known compounds 4-8 were isolated from the roots of Erythrina x bidwillii. Their structures were established on the basis of spectroscopic evidence. Among the isolated compounds, erythbidin E (3) showed a potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).