5-bromofurfural (E)-oxime | 4465-70-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 5-bromofurfural (E)-oxime
• 英文别名: 5-bromo-2-furyl oxime；syn-5-Brom-2-hydroxyiminomethyl-furan；2-Furancarboxaldehyde, 5-bromo-, oxime；N-[(5-bromofuran-2-yl)methylidene]hydroxylamine
• CAS: 4465-70-7
• 化学式: C₅H₄BrNO₂
• 分子量: 189.996
• InChiKey: IFWZXDMZYQEEFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-bromofurfural (E)-oxime 在 乙酸酐 作用下， 反应 17.0h， 生成 5-溴呋喃-2-甲腈
  参考文献：
  名称：

  [EN] OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS
  [FR] DERIVES D'OXAZOLIDINONES UTILISES EN TANT QU'ANTIMICROBIENS

  摘要：

  本发明涉及某些取代苯基噁唑烷酮的化合物（I）及其合成方法。该发明还涉及含有这些化合物作为抗微生物药物的药物组合物。这些化合物是有用的抗微生物剂，对多种人类和兽医病原体有效，包括革兰氏阳性厌氧细菌，如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧细菌，如拟杆菌属和梭菌属细菌，以及耐酸菌，如结核分枝杆菌、埃维分枝杆菌和分枝杆菌属。

  公开号：

  WO2005082899A1
• 作为产物：
  描述：

  5-溴-2-呋喃甲醛 在 盐酸羟胺 、 sodium carbonate 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以92.2%的产率得到5-bromofurfural (E)-oxime
  参考文献：
  名称：

  [EN] THIOPHENOXIME AND FURANOXIME SCAFFOLDS
  [FR] ÉCHAFAUDAGES DE THIOPHÈNEOXIME ET DE FURANOXIME

  摘要：

  本发明涉及一种化合物，其化学式为（I）。它还涉及一种药物组合物，包括至少一种化学式为（I）的化合物和至少一种药学上可接受的载体。最后，它涉及将这种化合物用作药物的用途，优选用于治疗由至少一种有机磷神经毒剂中毒引起的神经和/或呼吸衰竭；治疗神经疾病，如阿尔茨海默病；和/或治疗癌症。

  公开号：

  WO2022053628A1

文献信息

• Synthesis and biological evaluation of novel marine-derived indole-based 1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents
  作者：Cheng-Shi Jiang、Yan Fu、Li Zhang、Jing-Xu Gong、Zhen-Zhong Wang、Wei Xiao、Hai-Yan Zhang、Yue-Wei Guo

  DOI：10.1016/j.bmcl.2014.11.068

  日期：2015.1

  Phidianidines (1), isolated from the marine opisthobranch mollusk Phidiana militaris, present the first example of natural products possessing an 1,2,4-oxadiazole ring system and show various bioactivities. However, the structure-activity relationship study related to 1 has not been reported yet. As our ongoing effect toward marine-derived potential neuroprotective agents, a series of phidianidine-based derivatives have been synthesized and evaluated for neuroprotective effects against amyloid-beta(25-35) (A beta(25-35))-, hydrogenperoxide (H2O2)-, and oxygen-glucose deprivation (OGD)-induced neurotoxicity in SH-SY5Y cells. The bioassay results indicated that some of analogs, especially 2q and 2r, exhibited good in vitro neuroprotective effects in the above three screening models. The preliminary SAR study indicated that substituent groups introduced to the benzene ring play a crucial role in their bioactivity. In particular, the linear alkoxy group at 4-position favors the neuroprotective activity, while a bulky group could lead the activity decrease or loss. These findings could provide an alternative strategy for the development of novel indole-based 1,2,4-oxadiazole derivatives for the treatment of Alzheimer's disease. (C) 2014 Elsevier Ltd. All rights reserved.
• [EN] THIOPHENOXIME AND FURANOXIME SCAFFOLDS<br/>[FR] ÉCHAFAUDAGES DE THIOPHÈNEOXIME ET DE FURANOXIME
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2022053628A1

  公开（公告）日：2022-03-17

  The present invention relates to a compound of formula (I). It also relates to a pharmaceutical composition comprising at least one compound of formula (I) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and/or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and/or in the treatment of cancer.

  本发明涉及一种化合物，其化学式为（I）。它还涉及一种药物组合物，包括至少一种化学式为（I）的化合物和至少一种药学上可接受的载体。最后，它涉及将这种化合物用作药物的用途，优选用于治疗由至少一种有机磷神经毒剂中毒引起的神经和/或呼吸衰竭；治疗神经疾病，如阿尔茨海默病；和/或治疗癌症。
• [EN] OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS<br/>[FR] DERIVES D'OXAZOLIDINONES UTILISES EN TANT QU'ANTIMICROBIENS
  申请人：RANBAXY LAB LTD

  公开号：WO2005082899A1

  公开（公告）日：2005-09-09

  The present invention relates to certain substituted phenyl oxazolidinones of formula (I) and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing such compounds as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

  本发明涉及某些取代苯基噁唑烷酮的化合物（I）及其合成方法。该发明还涉及含有这些化合物作为抗微生物药物的药物组合物。这些化合物是有用的抗微生物剂，对多种人类和兽医病原体有效，包括革兰氏阳性厌氧细菌，如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧细菌，如拟杆菌属和梭菌属细菌，以及耐酸菌，如结核分枝杆菌、埃维分枝杆菌和分枝杆菌属。