N-(2-hydroxyethyl)-2-(2-hydroxyethylamino) acetamide | 144236-39-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-hydroxyethyl)-2-(2-hydroxyethylamino) acetamide
• 英文别名: N'-(2-Hydroxyethyl)-N-(2-hydroxyethyl)glycinamide；Heheaa；N-(2-hydroxyethyl)-2-(2-hydroxyethylamino)acetamide
• CAS: 144236-39-5
• 化学式: C₆H₁₄N₂O₃
• 分子量: 162.189
• InChiKey: IXMVWXRQTPARRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  81.6
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  C.I.酸性橙108 、 氯乙酰氯 以 乙醇 、 二氯甲烷 、 水 为溶剂， 生成 N-(2-hydroxyethyl)-2-(2-hydroxyethylamino) acetamide
  参考文献：
  名称：

  Composition for magnetic resonance imaging

  摘要：

  用于增强至少在温血动物部分的磁共振成像的方法和组合物。

  公开号：

  US05138040A1

文献信息

• Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases
  申请人：Aay Naing

  公开号：US20090156576A1

  公开（公告）日：2009-06-18

  Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

  本发明揭示了式(I)的化合物及其药学上可接受的盐和溶剂化物。这些化合物是MEK抑制剂，可用于治疗增生性疾病，如癌症。本发明还揭示了包含这些化合物的制药组合物，以及使用本发明的化合物和组合物治疗癌症的方法。
• NOVEL COMPOSITIONS FOR MAGNETIC RESONANCE IMAGING
  申请人：MALLINCKRODT MEDICAL, INC.

  公开号：EP0592474A1

  公开（公告）日：1994-04-20
• Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
  申请人：Miao Zhenwei

  公开号：US20090123968A1

  公开（公告）日：2009-05-14

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
• US5208375A
  申请人：——

  公开号：US5208375A

  公开（公告）日：1993-05-04
• US7803839B2
  申请人：——

  公开号：US7803839B2

  公开（公告）日：2010-09-28