5-ketogluconic acid | 13425-57-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 5-ketogluconic acid
• 英文别名: 5-Ketogluconsaeure；2,3,4,6-Tetrahydroxy-5-oxohexanoic acid
• CAS: 13425-57-5
• 化学式: C₆H₁₀O₇
• mdl: MFCD20643487
• 分子量: 194.141
• InChiKey: IZSRJDGCGRAUAR-UHFFFAOYSA-N

物化性质

• 沸点：
  650.9±55.0 °C(Predicted)
• 密度：
  1.757±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  135
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Synthesis of Furans from Sugars Via Keto Intermediates
  申请人：BP Corporation North America Inc.

  公开号：US20180057897A1

  公开（公告）日：2018-03-01

  The present invention provides a method of preparing a furan derivative comprising the steps of (a) converting a monosaccharide to provide a keto-intermediate product; and (b) dehydrating the keto-intermediate product to provide a furan derivative; wherein the keto-intermediate product is pre-disposed to forming keto-furanose tautomers in solution. The method may further comprising a step of oxidizing the furan derivative to provide a furandicarboxylic acid or a furandicarboxylic acid derivative.

  本发明提供了一种制备呋喃衍生物的方法，包括以下步骤：(a)将单糖转化为提供酮中间产物；(b)脱水酮中间产物以提供呋喃衍生物；其中酮中间产物预先倾向于在溶液中形成酮-呋喃糖异构体。该方法还可以包括将呋喃衍生物氧化以提供呋喃二羧酸或呋喃二羧酸衍生物的步骤。
• Process for preparing 4-hydroxy-5-methyl-2,3-dihydrofuranone-3 and changing organoleptic properties of foods
  申请人：UNILEVER N.V.

  公开号：EP0058870A1

  公开（公告）日：1982-09-01

  4-Hydroxy-5-methyl-2,3-dihydrofuranone-3 is obtained by heating a solution with pH between 1 and 7 of a 5-ketoaldohexonic acid or a derivative thereof in a polar solvent at a temperature of 70 °C to 150 °C. The 5-keto- aldohexonic acid is preferably 5-ketogluconic acid. Meat flavours are obtained by heating the 5-keto-aidohexonic acid unter the same conditions in the presence of a hydrogen sulphide donor like e.g. cysteine. This reaction product may be incorporated into foodstuffs. Also a process of modifying the organoleptic properties of a foodstuff or an ingredient for a foodstuff having a pH between 5 and 7 before consumption and which has to be heated at least 15 minutes to at least 70 °C by incorporating from 30 to 2000 ppm of a 5-keto-aidohexonic acid is described.

  4-羟基-5-甲基-2,3-二氢呋喃酮-3 是通过在极性溶剂中加热 pH 值介于 1 和 7 之间的 5-酮基-aldohexonic 酸或其衍生物溶液，在 70 °C 至 150 °C 的温度下得到的。5-Keto-aldohexonic acid 最好是 5-Ketogluconic acid。 在有硫化氢供体（如半胱氨酸）存在的情况下，在相同条件下加热 5-酮基-aldohexonic 酸，可获得肉味香精。这种反应产物可以加入食品中。此外，还介绍了一种通过加入 30 至 2000 ppm 的 5-酮-副己酸来改变食品或食品配料的感官特性的工艺，这种食品或食品配料在食用前的 pH 值在 5 至 7 之间，必须加热至少 15 分钟至至少 70 °C。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Synthesis of furans from sugars via keto intermediates
  申请人：BP Corporation North America Inc.

  公开号：US11193106B2

  公开（公告）日：2021-12-07

  The present invention provides a method of preparing a furan derivative comprising the steps of (a) converting a monosaccharide to provide a keto-intermediate product; and (b) dehydrating the keto-intermediate product to provide a furan derivative; wherein the keto-intermediate product is pre-disposed to forming keto-furanose tautomers in solution. The method may further comprising a step of oxidizing the furan derivative to provide a furandicarboxylic acid or a furandicarboxylic acid derivative.

  本发明提供了一种制备呋喃衍生物的方法，包括以下步骤：(a)转化单糖，提供酮中间产物；(b)脱水酮中间产物，提供呋喃衍生物；其中酮中间产物在溶液中预先形成酮-呋喃糖同系物。该方法可进一步包括氧化呋喃衍生物以提供呋喃二甲酸或呋喃二甲酸衍生物的步骤。
• PLANT RHAMNOGALACTURONAN II COMPLEXATION OF HEAVY METAL CATIONS
  申请人：UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：EP0939772A1

  公开（公告）日：1999-09-08