Yohimban | 875818-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Yohimban
• 英文别名: Alloyohimbane；1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban
• CAS: 875818-19-2
• 化学式: C₁₉H₂₄N₂
• 分子量: 280.413
• InChiKey: JUPDIHMJFPDGMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Diversion- and/or abuse-resistant aompositions and methods for making the same
  申请人：Losev Mikhail Viktorovich

  公开号：US20110207761A1

  公开（公告）日：2011-08-25

  A composition formulated for diversion- and/or abuse-resistance, includes at least one active pharmaceutical ingredient (API), each present in an acidic form, a first compound capable of coupling to the acidic form of the API to form a complex, where the resulting complex is resistant to separation by conventional separation methods, and a second compound capable of preferentially coupling to the first compound to thereby release the API from the complex.

  一种旨在防止滥用和/或耐受性的组合物，包括至少一种活性药物成分（API），每种API以酸性形式存在，第一化合物能够与API的酸性形式偶联形成复合物，所得到的复合物对传统的分离方法具有耐受性，以及第二化合物能够优先与第一化合物偶联，从而释放复合物中的API。
• Diversion - And/Or Abuse-Resistant Compositions And Methods For Making The Same
  申请人：Invincible Biotechnology, LLC

  公开号：US20150335593A1

  公开（公告）日：2015-11-26

  A composition formulated for diversion- and/or abuse-resistance, includes at least one active pharmaceutical ingredient (API), each present in an acidic form, a first compound capable of coupling to the acidic form of the API to form a complex, where the resulting complex is resistant to separation by conventional separation methods, and a second compound capable of preferentially coupling to the first compound to thereby release the API from the complex.

  一种旨在防止滥用和/或耐受性的配方，包括至少一种活性药物成分（API），每种成分以酸性形式存在，第一化合物能够与API的酸性形式偶联形成复合物，所得复合物对常规分离方法具有耐受性，第二化合物能够优先与第一化合物偶联，从而释放复合物中的API。
• SCREENING METHOD
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1860185A1

  公开（公告）日：2007-11-28

  The present invention provides compounds or their salts that promote or inhibit the activities of a protein comprising the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, compounds or their salts that promote or inhibit the activities of a gene for said protein, antisense polynucleotides comprising the whole or part of a base sequence complimentary or substantially complimentary to the base sequence of a polynucleotide encoding said protein or its partial peptide, antibodies to said protein, etc. These compounds or their salts, antisense nucleotides, antibodies, etc. can be used as agents for the prevention/treatment of mental disorders, prolactin-related disorders, etc.

  本发明提供了促进或抑制与 SEQ ID NO: 1 所代表的氨基酸序列相同或基本相同的蛋白质的活性的化合物或其盐类、促进或抑制所述蛋白质的基因的活性的化合物或其盐类、包含与编码所述蛋白质或其部分肽的多核苷酸的碱基序列全部或部分互补或基本互补的碱基序列的反义多核苷酸、所述蛋白质的抗体等。这些化合物或其盐、反义核苷酸、抗体等可用作预防/治疗精神疾病、催乳素相关疾病等的药物。
• DIVERSION-AND/OR ABUSE-RESISTANT COMPOSITIONS AND METHODS FOR MAKING THE SAME
  申请人：Medical Biological Union LLC

  公开号：EP2538779A1

  公开（公告）日：2013-01-02
• IMPROVED METHODS FOR MAKING AND USING POLYNUCLEOTIDE SEQUENCES IN THE SYNTHESIS OF ALKALOID COMPOUNDS
  申请人：Epimeron Inc.

  公开号：EP3137618A1

  公开（公告）日：2017-03-08

表征谱图