16,18-Dihydroxy-17-methoxy-1-methyl-13-oxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),3,5(9),12(19),14-pentaene-6,11-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 16,18-Dihydroxy-17-methoxy-1-methyl-13-oxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),3,5(9),12(19),14-pentaene-6,11-dione
• 化学式: C₂₀H₁₈O₆
• 分子量: 354.4
• InChiKey: JZAFRYPNQHUUMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Method for synthesizing furanosteroids
  申请人：Jacobi Peter A.

  公开号：US20090143346A1

  公开（公告）日：2009-06-04

  The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization of a functionalized alkyne oxazole to produce a furo[2,3-b]phenol derivative which is elaborated by intermolecular and intramolecular condensations to generate ring-A of the furanosteroid. Furanosteroids and pharmaceutical compositions containing the same are also provided.

  本发明涉及一种合成呋喃甾体的方法。该方法涉及分子内Diels-Alder/retro-Diels-Alder反应和一个官能化炔基噁唑的异构化，以产生一种furo[2,3-b]苯酚衍生物，通过分子间和分子内缩合反应来生成呋喃甾体的A环。同时还提供了呋喃甾体和含有其的药物组合物。
• COMPOSITIONS AND INTRALUMINAL DEVICES FOR INHIBITING VASCULAR STENOSIS
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP2012794B1

  公开（公告）日：2014-09-17
• METHODS AND COMPOSITIONS FOR TREATING NEOINTIMAL HYPERPLASIA
  申请人：Marks Andrew R.

  公开号：US20090274739A1

  公开（公告）日：2009-11-05

  The present invention relates to compositions containing an mTOR inhibitor, such as rapamycin or a rapamycin derivative, in combination with a PI3 kinase inhibitor and/or a leptin inhibitor, intraluminal devices configured to release such compositions, and methods for the treatment and/or prevention of intimal hyperplasia, vascular stenosis and/or restenosis comprising delivery of such compositions or intraluminal devices to subjects in need thereof. The compositions, intraluminal devices, and methods of the invention are particularly well-suited for the treatment or prevention of vascular stenosis and restenosis in obese and diabetic subjects.
• US8067583B2
  申请人：——

  公开号：US8067583B2

  公开（公告）日：2011-11-29
• [EN] COMPOSITIONS AND INTRALUMINAL DEVICES FOR INHIBITING VASCULAR STENOSIS<br/>[FR] COMPOSITIONS ET DISPOSITIFS INTRALUMINAUX PERMETTANT D'INHIBER LA STENOSE VASCULAIRE
  申请人：UNIV COLUMBIA

  公开号：WO2007120897A2

  公开（公告）日：2007-10-25

  [EN] The present invention relates to compositions containing rapamycin or rapamycin derivative in combination with a PI3 kinase inhibitor and/or a leptin inhibitor, intraluminal devices configured to release such compositions, and methods for the treatment and/or prevention of intimal hyperplasia, vascular stenosis and/or restenosis comprising delivery of such compositions or intraluminal devices to subjects in need thereof. The compositions, intraluminal devices, and methods of the invention are particularly well-suited for the treatment or prevention of vascular stenosis and restenosis in obese and diabetic subjects.
  [FR] L'invention concerne des compositions contenant de la rapamycine ou un dérivé de la rapamycine en combinaison avec un inhibiteur de la kinase PI3 et/ou avec un inhibiteur de la leptine, sur des dispositifs intraluminaux configurés pour libérer de telles compositions et sur des procédés permettant le traitement et/ou la prévention de l'hyperplasie intime, de la sténose et/ou de la resténose vasculaire comprenant l'administration de telles compositions ou dispositifs intraluminaux aux sujets en ayant. Les compositions, dispositifs intraluminaux et procédés de l'invention sont particulièrement bien adaptés au traitement ou à la prévention de la sténose vasculaire et de la resténose vasculaire chez des sujets obèses et diabétiques.