lactobionic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: lactobionic acid
• 英文别名: 2,3,5,6-Tetrahydroxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoic acid
• 化学式: C₁₂H₂₂O₁₂
• 分子量: 358.299
• InChiKey: JYTUSYBCFIZPBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  218
• 氢给体数：
  9
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  lactobionic acid 在 三氟乙酸 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 Lactobionic acid, delta-lactone
  参考文献：
  名称：

  氧化还原反应性两亲喜树碱前药纳米颗粒，用于靶向肝肿瘤治疗。

  摘要：

  靶向肿瘤细胞的药物递送系统对于临床中的抗肿瘤治疗非常重要。由于去唾液酸糖蛋白受体（ASGPR）在肝癌细胞膜上的过表达，在药物递送系统表面结合乳糖已经显示出靶向肿瘤细胞的显着优势。在这项研究中，合成了由喜树碱（CPT）和乳糖（LA）组成的二硫键结合的前药靶向递送系统，称为CPT-SS-LA。喜树碱和乳糖分别在药物递送系统中充当化疗药物和靶向配体。由于CPT-SS-LA是两亲性化合物，因此它可以自组装成直径约为110 nm的纳米颗粒。CPT-SS-LA纳米颗粒在生理环境中显示出可控的药物释放行为。与游离的CPT不同，CPT-SS-LA纳米颗粒首先通过增强的通透性和保留（EPR）效应组装在肿瘤部位，然后被具有ASGP受体介导的内吞作用的肿瘤细胞吞噬。最后，释放出抗肿瘤药CPT来杀死具有高谷胱甘肽（GSH）浓度环境的肿瘤细胞。在体外，纳米颗粒显示出靶向肝癌癌细胞而不是正常的HUVEC细胞的良好能力

  DOI：

  10.1039/d0tb00285b

文献信息

• Compositions and kits for enhancing delivery of therapeutic agents to cells
  申请人：CANJI, Inc.

  公开号：EP2106807A1

  公开（公告）日：2009-10-07

  This invention provides a composition comprising a delivery enhancing compound and a kit for delivering an agent to cells comprising a vial with a therapeutic agent and a vial with said composition. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The kit is useful for introducing agents into cells that are present as a tissue or organ, in particular into cancer cells.

  本发明提供了一种包含递送增强化合物的组合物和一种用于向细胞递送药剂的试剂盒，该试剂盒包括一个装有治疗剂的小瓶和一个装有所述组合物的小瓶。药剂可包括多肽、基因和反义核酸等多核苷酸以及其他分子。在某些实施方案中，药剂是调节剂，引入细胞后可调节细胞活性或功能。该试剂盒适用于将药剂导入作为组织或器官存在的细胞，特别是导入癌细胞。
• Borate esters
  申请人：Lombardi John L.

  公开号：US10364325B2

  公开（公告）日：2019-07-30

  A method to prepare a borate complexed polyalkylguanidinium polymer, the method including heating bis(hexamethylene triamine and guanidine chloride to prepare a polyalkylguanidinium chloride, reacting the polyalkylguanidinium chloride with glycidol in an equimolar amount of glycidol and secondary amine functionalities present in the polyalkylguanidinium chloride to prepare a N-2,3-dihydroxypropyl polyalkylguanidinium chloride polymer, and reacting the N-2,3-dihydroxypropyl polyalkylguanidinium chloride polymer with a boron-oxide material to prepare the borate complexed polyalkylguanidinium polymer.

  一种制备硼酸盐络合聚烷基胍聚合物的方法，该方法包括加热双六亚甲基三胺和氯化胍以制备聚烷基氯化胍，以等摩尔量的缩水甘油和存在于聚烷基氯化胍中的仲胺官能团使聚烷基氯化胍与缩水甘油反应以制备N-2、3-二羟丙基聚烷基氯化胍聚合物，并使 N-2，3-二羟丙基聚烷基氯化胍聚合物与氧化硼材料反应，制备硼酸盐络合聚烷基氯化胍聚合物。
• SYN3 COMPOSITIONS AND METHODS
  申请人：Ihnat Peter M.

  公开号：US20100324126A1

  公开（公告）日：2010-12-23

  Disclosed are aqueous and nonaqueous solution formulations containing agents that are useful for treating cancer.
• BIODEGRADABLE SUTURE TYPE CELL DELIVERY SYSTEM FOR IMPROVING STEM CELL ENGRAFTMENT RATE
  申请人：Chun Heung Jae

  公开号：US20120078297A1

  公开（公告）日：2012-03-29

  The present invention relates to a biodegradable suture-type cell delivery system, a preparation method thereof and a biodegradable suture comprising the same. The biodegradable suture-type cell delivery system has improved cell compatibility as a result of depositing a hydrophilic functional group-containing compound on the surface of a biodegradable suture yarn made of a biodegradable polymer, a portion of which has partially a bulky structure beneficial for the proliferation of cells or living tissue, so as to hydrophilically modify the surface, and then bonding a cell compatible material to the surface, and also functions as a cell culture scaffold, because the bulky structure is beneficial for the proliferation of cells. Accordingly, the biodegradable suture-type cell delivery system can improve the rate of engraftment of stem cells in vivo.
• BORATE ESTERS
  申请人：Lombardi John L.

  公开号：US20150376336A1

  公开（公告）日：2015-12-31

  A method to prepare a borate complexed polyalkylguanidinium polymer, the method including heating bis(hexamethylene triamine and guanidine chloride to prepare a polyalkylguanidinium chloride, reacting the polyalkylguanidinium chloride with glycidol in an equimolar amount of glycidol and secondary amine functionalities present in the polyalkylguanidinium chloride to prepare a N-2,3-dihydroxypropyl polyalkylguanidinium chloride polymer, and reacting the N-2,3-dihydroxypropyl polyalkylguanidinium chloride polymer with a boron-oxide material to prepare the borate complexed polyalkylguanidinium polymer.