Calcium;4-methylbenzenesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Calcium;4-methylbenzenesulfonate
• 化学式: C14H14CaO6S2
• 分子量: 382.5
• InChiKey: GVARKRUZKAZPOZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.42
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  calcium carbonate 、 对甲苯磺酸 反应 1.0h， 生成 Calcium;4-methylbenzenesulfonate
  参考文献：
  名称：

  Coated inorganic materials

  摘要：

  一种无机粉状或颗粒状物质，其表面覆盖有一层本质导电的聚合物材料涂层，例如导电聚吡咯或取代聚吡咯、聚噻吩或取代聚噻吩、聚苯胺或取代聚苯胺、聚乙烯氧化物或苯胺共聚物。被涂层的材料可以是滑石粉、云母、硅灰石、碳酸钙、氢氧化铝、粘土或羟基磷灰石。

  公开号：

  US04937060A1

文献信息

• Process to obtain a mixture of lower carboxylic mono, di and triesters from raw glycerin
  申请人：Rhodia Poliamida E Especialidades Ltda

  公开号：EP2272818A1

  公开（公告）日：2011-01-12

  The present invention concerns an optimized process to obtain a mixture of lower carboxylic acid mono, di and triesters, from raw glycerin, a by-product of the process to obtain biodiesel, a transesterification of vegetable raw material with lower alcohols. The invention particularly refers to an optimized process to obtain triacetin or a mixture of mono-, di- and triacetin from that raw glycerin, without prior purification.

  本发明涉及一种优化工艺，用于从生甘油中获得一种混合物，其中包含较低羧酸单酯、二酯和三酯，生甘油是生物柴油制备过程中的副产品，即将植物原料与低级醇进行酯交换反应。该发明特别涉及一种优化工艺，用于从该生甘油中获得三乙酸甘油酯或一种不经预先纯化的单酯、二酯和三酯混合物。
• [EN] PROCESS TO OBTAIN A MIXTURE OF LOWER CARBOXYLIC MONO, DI AND TRIESTERS FROM RAW GLYCERIN<br/>[FR] PROCÉDÉ PERMETTANT D'OBTENIR UN MÉLANGE DE MONOESTER, DIESTER ET TRIESTER D'ACIDE CARBOXYLIQUE INFÉRIEUR À PARTIR DE GLYCÉROL BRUT
  申请人：RHODIA POLIAMIDA E ESPECIALIDADES LTDA

  公开号：WO2011001249A1

  公开（公告）日：2011-01-06

  The present invention concerns an optimized process to obtain a mixture of lower carboxylic acid mono, di and triesters, from raw glycerin, a by-product of the process to obtain biodiesel, a transesterification of vegetable raw material with lower alcohols. The invention particularly refers to an optimized process to obtain triacetin or a mixture of mono-, di- and triacetin from that raw glycerin, without prior purification.

  本发明涉及一种优化的工艺，用于从生甘油中获得一种混合物，其中包括低级羧酸单酯、二酯和三酯，生甘油是生物柴油制备过程中的副产品，即植物原料与低级醇进行酯交换反应的过程。该发明特别涉及一种优化的工艺，用于从该生甘油中获得三乙酸甘油酯或单酯、二酯和三酯的混合物，无需事先纯化。
• SOLID STATE FORMS OF DEFERASIROX SALTS AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Neela Praveen Kumar

  公开号：US20110097413A1

  公开（公告）日：2011-04-28

  Provided herein are novel solid state forms of deferasirox salts, process for the preparation, pharmaceutical compositions, and method of treating thereof. The solid state forms of deferasirox salts are useful for preparing deferasirox (I) in high purity.

  本文提供了新型固态形式的去铁医药盐，其制备方法，制药组合物以及治疗方法。这些去铁医药盐的固态形式有助于高纯度地制备去铁医药(I)。
• Amorphous Coprecipitates of Atorvastatin Pharmaceutically Acceptable Salts
  申请人：Dixit Girish

  公开号：US20110142883A1

  公开（公告）日：2011-06-16

  The present invention relates to stable amorphous co-precipitates of atorvastatin pharmaceutically acceptable salts with pharmaceutically acceptable excipients, method for the preparation, pharmaceutical compositions, and method of treating thereof. Advantageously, the amorphous co-precipitates of atorvastatin pharmaceutically acceptable salts of the present invention have improved physiochemical characteristics that assist in the effective bioavailability

  本发明涉及阿托伐他汀药物可接受盐与药物可接受辅料的稳定非晶共沉淀物、制备方法、制药组合物及其治疗方法。有益的是，本发明的阿托伐他汀药物可接受盐的非晶共沉淀物具有改善的物理化学特性，有助于有效的生物利用度。
• Novel Polymorph of Atorvastatin Calcium and Use Thereof for the Preparation of Amorphous Atorvastatin Calcium
  申请人：Dixit Girish

  公开号：US20100260851A1

  公开（公告）日：2010-10-14

  The present invention provides a novel polymorphic form of atorvastatin calcium, designated as form Al, process for preparation, pharmaceutical compositions, and method of treating thereof. The present invention further provides a process for the preparation of highly pure amorphous atorvastatin calcium using the novel atorvastatin calcium form Al. The present invention also relates to novel amorphous form of atorvastatin tert-butyl ester, chemically known as [R-(R*,R*)]-2-(4-fluorophenyl)-[β],[δ]-dihydroxy -5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl-1H-pyrrole-1-heptanoicacid tert-butyl ester, process for the preparation, and its application for preparing highly pure atorvastatin and its pharmaceutically acceptable salts thereof. The present invention also relates to use of the novel amorphous atorvastatin tert-butyl ester and novel atorvastatin calcium form al for preparing amorphous atorvastatin calcium.

  本发明提供了阿托伐他汀钙的一种新的多晶形式，称为Al型，制备方法、制药组合物和治疗方法。本发明还提供了一种使用新的阿托伐他汀钙Al型制备高纯非晶态阿托伐他汀钙的方法。本发明还涉及阿托伐他汀叔丁基酯的新非晶态形式，化学名称为[R-(R*，R*)]-2-(4-氟苯基)-[β]，[δ]-二羟基-5-(1-甲基乙基)-3-苯基-4-(苯基羰氨基)-1H-吡咯烷-1-庚酸叔丁基酯，制备方法及其应用于制备高纯阿托伐他汀及其药用盐。本发明还涉及使用新的非晶态阿托伐他汀叔丁基酯和新的阿托伐他汀钙Al型制备非晶态阿托伐他汀钙。