glyceryl-1-tetracosanoate | 118605-21-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: glyceryl-1-tetracosanoate
• 英文别名: glycerol-α-lignocerate；2,3-dihydroxypropyl tetracosanoate
• CAS: 118605-21-3
• 化学式: C₂₇H₅₄O₄
• 分子量: 442.723
• InChiKey: KIWLCEXSSGNBJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  31
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  glyceryl-1-tetracosanoate 、 水 生成 甘油 、 氢(+1)阳离子 、 肉豆蔻酸癸酯
  参考文献：
  名称：

  Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids

  摘要：

  Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract (PHARC) is a rare genetic human neurological disorder caused by null mutations to the Abhd12 gene, which encodes the integral membrane serine hydrolase enzyme ABHD12. Although the role that ABHD12 plays in PHARC is understood, the thorough biochemical characterization of ABHD12 is lacking. Here, we report the facile synthesis of mono-1-(fatty)acyl-glycerol lipids of varying chain lengths and unsaturation and use this lipid substrate library to biochemically characterize recombinant mammalian ABHD12. The substrate profiling study for ABHD12 suggested that this enzyme requires glycosylation for optimal activity and that it has a strong preference for very-long-chain lipid substrates. We further validated this substrate profile against brain membrane lysates generated from WT and ABHD12 knockout mice. Finally, using cellular organelle fractionation and immunofluorescence assays, we show that mammalian ABHD12 is enriched on the endoplasmic reticulum membrane, where most of the very-long-chain fatty acids are biosynthesized in cells. Taken together, our findings provide a biochemical explanation for why very-long-chain lipids (such as lysophosphatidylserine lipids) accumulate in the brains of ABHD12 knockout mice, which is a murine model of PHARC.

  DOI：

  10.1074/jbc.ra118.005640
• 作为产物：
  描述：

  lignoceroyl chloride 在 吡啶 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 15.5h， 生成 glyceryl-1-tetracosanoate
  参考文献：
  名称：

  Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

  摘要：

  合成的甘油酯衍生物具有简单的烷基链，可刺激与先天性免疫系统相关的 Mincle 介导的信号检测。

  DOI：

  10.1039/c8cc07322h

文献信息

• Compositions and methods for using acyltransferases for altering lipid production on the surface of plants
  申请人：Li Yonghua

  公开号：US20090163729A1

  公开（公告）日：2009-06-25

  The present invention relates to compositions comprising acyltransferase nucleic acid molecules for altering lipids on the surface of plants, and related methods. In particular, the present invention provides compositions and methods for increasing the amount of free fatty acids, acylglycerols, and other lipids on the surface of a plant. In a preferred embodiment, the present invention relates to increasing activity of a GPAT acyltransferase for altering lipid on the plant surface, for increasing surface lipids, for enhancing environmental stress tolerance, increasing resistance to biotic stress, and providing novel plant lipids for commercial products. In further embodiments, the present invention relates to using an Arabidopsis thaliana GPAT acyltransferase for altering lipid compounds on the surface of a plant.
• TONER FOR ELECTROPHOTOGRAPHY AND TONER SET
  申请人：Iwamoto Ryohei

  公开号：US20120208119A1

  公开（公告）日：2012-08-16

  A toner for electrophotography characterized in that, when a monochromatic image of the toner for electrophotography is formed and the reflection absorption spectrum thereof is measured, said reflection absorption spectrum shows a maximum density within a range of 600-700 nm, and, excluding the light absorption by a substrate, the maximum density (Dm) of said reflection absorption spectrum, the density thereof at 570 nm (D(570)) and the density thereof at 530 nm (D(530)) satisfy the following requirements, and a toner set for electrophotography: 1.4≦Dm≦3.5, D(570)≧0.55 and 4.5≦D(570)/D(530)≦12.
• PRODUCTION PROCESS FOR COLORANT, COLORANT COMPOSITION, TONER, INK FOR INK JET RECORDING AND COLOR FILTER
  申请人：ISHIDAI Keiko

  公开号：US20130260306A1

  公开（公告）日：2013-10-03

  Provided is a production process for a colorant which contains a silicon phthalocyanine compound making it possible to reach a targeted particle diameter even by a conventional dispersing method and which is excellent in performances such as a color reproducibility, a light fastness, an electrostatic property, a transparency and the like, and a colorant composition, a toner, an ink for ink jet recording and a color filter which are excellent in the above performances. The above production process is a production process for a colorant containing a silicon phthalocyanine compound and a copper phthalocyanine compound and is characterized by having a preparing step of reacting raw materials of a silicon compound and phthalocyanine under the presence of a copper salt or the copper phthalocyanine compound described above to prepare the silicon phthalocyanine compound described above.
• US9062225B2
  申请人：——

  公开号：US9062225B2

  公开（公告）日：2015-06-23
• [EN] COMPOSITIONS AND METHODS FOR USING ACYLTRANSFERASES FOR ALTERING LIPID PRODUCTION ON THE SURFACE OF PLANTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS UTILISANT DES ACYLTRANSFÉRASES POUR MODIFIER LA PRODUCTION DE LIPIDES SUR LA SURFACE DE PLANTES
  申请人：UNIV MICHIGAN STATE

  公开号：WO2007149583A2

  公开（公告）日：2007-12-27

  [EN] The present invention relates to compositions comprising acyltransferase nucleic acid molecules for altering lipids on the surface of plants, and related methods. In particular, the present invention provides compositions and methods for increasing the amount of free fatty acids, acylglycerols, and other lipids on the surface of a plant. In a preferred embodiment, the present invention relates to increasing activity of a GPAT acyltransferase for altering lipid on the plant surface, for increasing surface lipids, for enhancing environmental stress tolerance, increasing resistance to biotic stress, and providing novel plant lipids for commercial products. In further embodiments, the present invention relates to using an Arabidopsis thaliana GPAT acyltransferase for altering lipid compounds on the surface of a plant.
  [FR] La présente invention concerne des compositions comprenant des molécules d'acides nucléiques d'acyltransférases servant à modifier les lipides sur la surface de plantes et des procédés concernant celles-ci. En particulier, la présente invention concerne des compositions et des procédés servant à accroître la quantité d'acides gras libres, d'acylglycérols et d'autres lipides sur la surface d'une plante. Dans un mode de réalisation préféré, la présente invention concerne l'augmentation de l'activité d'une acyltransférase de type GPAT pour modifier les lipides sur la surface de plantes, pour augmenter les lipides de surface, pour accroître la tolérance aux contraintes environnementales, pour augmenter la résistance aux contraintes biotiques et pour fournir de nouveaux lipides végétaux pour des produits industriels. Dans d'autres modes de réalisation, la présente invention concerne l'utilisation d'une acyltransférase de type GPAT de Arabidopsis thaliana pour modifier les composés lipides sur la surface d'une plante.