hydron;(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 1H-indole-3-carboxylate;chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: hydron;(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 1H-indole-3-carboxylate;chloride
• 化学式: C17H21ClN2O2
• 分子量: 320.8
• InChiKey: XIEGSJAEZIGKSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  45.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Thieno 3,2-b pyridine derivatives for the treatment of gastrointestinal disorders
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0560348B1

  公开（公告）日：2002-07-10
• US4910193A
  申请人：——

  公开号：US4910193A

  公开（公告）日：1990-03-20
• [EN] METHODS, COMPOSITIONS AND COMPOUND ASSAYS FOR INHIBITING AMYLOID-BETA PROTEIN PRODUCTION<br/>[FR] PROCEDES, COMPOSITIONS ET ESSAIS SUR COMPOSES POUR L'INHIBITION DE LA PRODUCTION DE LA PROTEINE BETA-AMYLOIDE
  申请人：GALAPAGOS GENOMICS NV

  公开号：WO2005119262A2

  公开（公告）日：2005-12-15

  A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a HIT polypeptide, or fragment thereof, and measuring a compound-HIT property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including cleaved protease substrates, phosphorylated kinase substrate, second messenger levels and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of HIT expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimer's disease.