pseudo glycyl leucine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: pseudo glycyl leucine
• 英文别名: 2-[[azaniumylmethyl(hydroxy)phosphoryl]methyl]-4-methylpentanoate
• 化学式: C₈H₁₈NO₄P
• 分子量: 223.209
• InChiKey: KOFLYAUGTQFODT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-hydroxyphosphinoylmethyl-4-methyl-pentanoic acid ethyl ester 在 盐酸 、 乙酰氯 作用下， 以 水 、 乙酸酐 为溶剂， 反应 32.0h， 生成 pseudo glycyl leucine
  参考文献：
  名称：

  Synthesis of phosphorus isosters of β-amyloid peptides fragments

  摘要：

  We have developed a synthetic route to pseudo dipeptides, analogs of certain fragments of beta-amyloid peptides (products of the APP protein hydrolysis). These compounds can be used for preparation of phosphinic acidic oligopeptides representing the peptide sequence of the beta-amyloid but containing the phosphorus isoster peptide fragment. Synthesis of pseudo ornityl-glutamate, pseudo arginyl-glutamate, pseudo glycyl-leucine, and pseudo isoleucyl-glycine via amino- and amidoalkylation of phosphonic acids containing the structural isoster of the corresponding amino acid is described.

  DOI：

  10.1134/s1070363215090121

文献信息

• Synthesis of phosphorus isosters of β-amyloid peptides fragments
  作者：M. E. Dmitriev、V. V. Ragulin

  DOI：10.1134/s1070363215090121

  日期：2015.9

  We have developed a synthetic route to pseudo dipeptides, analogs of certain fragments of beta-amyloid peptides (products of the APP protein hydrolysis). These compounds can be used for preparation of phosphinic acidic oligopeptides representing the peptide sequence of the beta-amyloid but containing the phosphorus isoster peptide fragment. Synthesis of pseudo ornityl-glutamate, pseudo arginyl-glutamate, pseudo glycyl-leucine, and pseudo isoleucyl-glycine via amino- and amidoalkylation of phosphonic acids containing the structural isoster of the corresponding amino acid is described.