p-iso-Butyl-oxy-benzoesaeure | 104097-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-iso-Butyl-oxy-benzoesaeure
• 英文别名: 4-sec-butoxy-benzoic acid；(+/-)-4-sec-Butyloxy-benzoesaeure；4-sec-Butoxy-benzoesaeure；4-[(1-methylpropyl)oxy]benzoic acid；4-Sec-butoxybenzoic acid；4-butan-2-yloxybenzoic acid
• CAS: 104097-41-8
• 化学式: C₁₁H₁₄O₃
• mdl: MFCD01333527
• 分子量: 194.23
• InChiKey: LCMFDJQAHNDLEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  p-iso-Butyl-oxy-benzoesaeure 、 4-(1,3-苯并噻唑-2-甲基)苯胺 在 氯化亚砜 、 碳酸氢钠 作用下， 以 苯 、 乙醚 、 水 为溶剂， 反应 3.0h， 以34%的产率得到2-[4-(4-sec-butoxybenzamido)benzyl]benzothiazole
  参考文献：
  名称：

  Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl / phenyl)benzothiazoles

  摘要：

  A new series of 2-[4-(4-substitutedbenzamido / phenylacetamido / phenylpropionamido) benzyl / phenyl]benzothiazole derivatives (6a-6w) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 200 and 6.25 mu g/ml. Compounds 6e and 6j exhibited the greatest activity with MIC values of 6.25 mu g/ml against Pseudomonas aeruginosa, and Staphylococcus aureus isolate, respectively.

  DOI：

  10.5562/cca2064
• 作为产物：
  描述：

  2-溴丁烷 、 对羟基苯甲酸甲酯 在 甲醇 、 sodium methylate 作用下， 生成 p-iso-Butyl-oxy-benzoesaeure
  参考文献：
  名称：

  哌啶衍生物；从取代的哌啶醇衍生的局部麻醉剂。

  摘要：

  DOI：

  10.1021/ja01216a051

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：GLAXO GROUP LTD

  公开号：WO2009133136A1

  公开（公告）日：2009-11-05

  The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

  这项发明涉及具有药理活性的新型噁二唑衍生物，其制备方法，含有它们的药物组合物以及它们在治疗各种疾病中的用途。
• COMPOUNDS
  申请人：Eldred Colin David

  公开号：US20110039889A1

  公开（公告）日：2011-02-17

  The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

  本发明涉及具有药理活性的新型噁唑啉衍生物，其制备方法，含有它们的制药组合物以及它们在治疗各种疾病中的应用。
• Preparation of olefin polymerization catalyst component
  申请人：SHELL OIL COMPANY

  公开号：EP0292134A2

  公开（公告）日：1988-11-23

  Solid catalyst component for use in the polymerization of olefins and having improved activity and selectivity are prepared by: a) halogenating a magnesium compound containing at least one aryloxy, alkyl carbonate or alkyloxy group with a first halide of tetravalent titanium and a first electron donor; b₁) contacting the resulting halogenated product with a second halide of tetravalent titanium; and c) washing a resulting treated halogenated product with an inert hydrocarbon liquid, wherein a second electron donor is used in step a) or step b₁) and in that the product of step b₁) is contacted in step b₂ with a third halide of tetravalent titanium at a temperature of 40° to 140°C and thereafter the treated product is washed in step c).

  通过以下方法制备了用于烯烃聚合且活性和选择性得到改善的固体催化剂组分： a) 将含有至少一个芳氧基、碳酸烷基酯或烷氧基的镁化合物与四价钛的第一卤化物和 第一电子供体卤化； b₁) 将得到的卤化产物与四价钛的第二卤化物接触；以及 c) 用惰性烃类液体洗涤处理后的卤化产物，其中第二电子供体用于步骤 a) 或步骤 b₁)，步骤 b₁)中的产物在步骤 b₂ 中与四价钛的第三卤化物在 40° 至 140°C 的温度下接触，然后在步骤 c) 中洗涤处理后的产物。
• Propylene polymers and their production
  申请人：SHELL OIL COMPANY

  公开号：EP0320150A2

  公开（公告）日：1989-06-14

  An ultra high molecular melt flow rate propylene polymer in which the molecular weight distribution Q is not inversely proportional to the melt flow rate is produced, without post-reactor treatment, by contacting propylene and hydrogen, in the gas phase in the presence of a high activity catalyst.

  一种分子量分布 Q 与熔体流动速率不成反比的超高分子熔体流动速率丙烯聚合物，是在一种高活性催化剂存在下，通过气相中丙烯与氢的接触，在不进行反应后处理的情况下生产出来的。
• Film for optical elements
  申请人：Nippon Mitsubishi Oil Corporation

  公开号：EP0982621A2

  公开（公告）日：2000-03-01

  A film for optical elements is formed by a liquid crystalline composition comprising the following components (a) and (b): (a) a liquid crystalline polymer which exhibits an optically positive uniaxial property; and (b) a polycyclic compound having a molecular weight of not more than 1,000 and wherein a plurality of alicyclic rings and/or aromatic rings are connected together through a linkage chain of 0 to 4 main-chain carbon atoms bonded to different ring carbon atoms, with hydrocarbon groups each having 1 to 20 carbon atoms being bonded respectively to both end rings through a linkage chain of 0 to 4 main-chain carbon atoms,    an orientation form formed in the state of liquid crystal of said liquid crystalline composition being fixed.

  用于光学元件的薄膜由液晶组合物形成，液晶组合物包括以下成分 (a) 和 (b)： (a) 具有光学正单轴性的液晶聚合物；和 (b) 多环化合物，其分子量不超过 1,000，其中多个脂环和/或芳香环通过 0 至 4 个主链碳原子的连接链连接在一起，这些主链碳原子与不同的环碳原子键合，而每个具有 1 至 20 个碳原子的烃基通过 0 至 4 个主链碳原子的连接链分别与两个端环键合、 所述液晶组合物在液晶状态下形成的取向形式是固定的。