Formiminoglycin | 2140-03-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Formiminoglycin
• 英文别名: Formimidoylglycine；[(Iminiomethyl)amino]acetate；2-(aminomethylideneazaniumyl)acetate
• CAS: 2140-03-6
• 化学式: C₃H₆N₂O₂
• mdl: MFCD00021746
• 分子量: 102.093
• InChiKey: LLKCTZRWBHOKFF-UHFFFAOYSA-N

物化性质

• 熔点：
  217 °C (decomp)
• 沸点：
  237.4±42.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  75.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  Formiminoglycin 、 alkaline earth salt of/the/ methylsulfuric acid 在 liverextract 作用下， 生成 S-(5'-腺苷)-L-高半胱氨酸
  参考文献：
  名称：

  THE FORMATION OF S-ADENOSYLHOMOCYSTEINE IN ENZYMATIC TRANSMETHYLATION REACTIONS¹

  摘要：

  DOI：

  10.1021/ja01647a081
• 作为产物：
  描述：

  甲脒盐酸盐 、 聚甘氨酸 在 吡啶 、 formamide 作用下， 生成 Formiminoglycin
  参考文献：
  名称：

  Micheel; Flitsch, Justus Liebigs Annalen der Chemie, 1952, vol. 577, p. 234,236

  摘要：

  DOI：

文献信息

• Purine metabolism in Methanococcus vannielii
  作者：E DeMoll、T Auffenberg

  DOI：10.1128/jb.175.18.5754-5761.1993

  日期：1993.9

  Methanococcus vannielii is capable of degrading purines to the extent that each of these purines may serve as the sole nitrogen source for growth. Results presented here demonstrate that purine degradation by M. vannielii is accomplished by a route similar to that described for clostridia. Various characteristics of the purine-degrading pathway of M. vannielii are described. Additionally, it is shown that M. vannielii does not extensively degrade exogenously supplied guanine if that compound is present at levels near or lower than those required to supply the cellular guanine requirement. Under those conditions, M. vannielii incorporates the intact guanine molecule into its guanine nucleotide pool. The benefits of a purine-degrading pathway to methanogens are discussed.

  Methanococcus vannielii能够降解嘌呤，以至于每种嘌呤都可以作为其生长的唯一氮源。本文的结果表明，M. vannielii通过与梭菌相似的途径实现了嘌呤的降解。描述了M. vannielii嘌呤降解途径的各种特性。此外，研究表明，如果外源供应的鸟嘌呤的含量接近或低于细胞鸟嘌呤需求的水平，M. vannielii不会广泛降解鸟嘌呤。在这些条件下，M. vannielii将完整的鸟嘌呤分子并入其鸟嘌呤核苷酸库中。本文还讨论了嘌呤降解途径对甲烷菌的益处。
• Micheel et al., Justus Liebigs Annalen der Chemie, 1952, vol. 575, p. 90,103
  作者：Micheel et al.

  DOI：——

  日期：——
• Freter et al., Justus Liebigs Annalen der Chemie, 1957, vol. 607, p. 174,178
  作者：Freter et al.

  DOI：——

  日期：——
• Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model
  作者：Tao Yu、Chengde Wu、NengYang Shih、Qi Li、Chichung Chan、He Pan、Dan Yao、Yan Pan、Wei Liang、Liang Shen、Hui Zhao、Jian Li、Shuhui Chen

  DOI：10.1016/j.bmcl.2018.04.051

  日期：2018.6

  Diacylglycerol acyltransferase (DGAT) is expressed abundantly in intestine, liver, and adipose tissues. DGAT1 is the crucial and rate-limiting enzyme that mediates the final step in triacylglycerol (TAG) resynthesis during dietary fat absorption. However, too much triacylglycerol (TAG) reserve will lead to genetic obesity (Hubert et al., 2000). DGAT1 knockout mice could survive and displayed a reduction in the postprandial rise of plasma TG, and increased sensitivity of insulin and leptin. Here we report the discovery and characterization of a novel selective DGAT1 inhibitor 29 to potentially treat obesity. Compound 29 showed lipid lowering effect in mouse lipid tolerance test (LTT) and also reduced body weight in DIO mice without observable liver damage. (C) 2018 Elsevier Ltd. All rights reserved.
• Tabor; Rabinowitz, Biochemical Preparations, 1957, vol. 5, p. 100,103
  作者：Tabor、Rabinowitz

  DOI：——

  日期：——