1H-indole-2,4-dicarboxylic acid 4-methyl ester | 1159512-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1H-indole-2,4-dicarboxylic acid 4-methyl ester
• 英文别名: 4-methoxycarbonyl-1H-indole-2-carboxylic acid
• CAS: 1159512-00-1
• 化学式: C₁₁H₉NO₄
• 分子量: 219.197
• InChiKey: PJROITSVDOANGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  79.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1H-Indole-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester 在 三氟乙酸 作用下， 反应 1.0h， 生成 1H-indole-2,4-dicarboxylic acid 4-methyl ester
  参考文献：
  名称：

  Indole derivatives as factor Xa inhibitors

  摘要：

  本发明涉及一种具有化学式I的化合物，用于抑制因子Xa的活性。本发明还涉及含有上述化合物的组合物，其制备过程，以及它们的用途，例如用于抑制凝血酶的形成，或用于治疗或预防患有与心血管疾病有关的疾病状态的患者。

  公开号：

  US20050033049A1

文献信息

• NEW INDOLE DERIVATIVES AS FACTOR XA INHIBITORS
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1633746A1

  公开（公告）日：2006-03-15
• US7196103B2
  申请人：——

  公开号：US7196103B2

  公开（公告）日：2007-03-27
• [EN] NEW INDOLE DERIVATIVES AS FACTOR XA INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS D'INDOLE EN TANT QU'INHIBITEURS DU FACTEUR XA
  申请人：AVENTIS PHARMA GMBH

  公开号：WO2004101554A1

  公开（公告）日：2004-11-25

  The present invention relates to compounds of the formula (I) in which R0 ; R1 ; R2 ; R3 ; R4 ; R5 ; R6 ; R7 ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor Vila (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor Vila is present or for the cure or prevention of which an inhibition of factor Xa and/or factor Vila is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
• Indole derivatives as factor Xa inhibitors
  申请人：Nazare Marc

  公开号：US20050033049A1

  公开（公告）日：2005-02-10

  The present invention is directed to the compound of formula I which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as for inhibiting the formation of thrombin or for therapeutically or prophylactically treating a patient suffering from, or subject to, or associated with a disease state associated with a cardiovascular disorder.

  本发明涉及一种具有化学式I的化合物，用于抑制因子Xa的活性。本发明还涉及含有上述化合物的组合物，其制备过程，以及它们的用途，例如用于抑制凝血酶的形成，或用于治疗或预防患有与心血管疾病有关的疾病状态的患者。