N,N-diethyl-1-pyrenylmethylamine | 3712-78-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: N,N-diethyl-1-pyrenylmethylamine
• 英文别名: 1-Diaethylaminomethyl-pyren；Diaethyl--amin；Diethylaminomethyl pyrene；N-ethyl-N-(pyren-1-ylmethyl)ethanamine
• CAS: 3712-78-5
• 化学式: C₂₁H₂₁N
• 分子量: 287.404
• InChiKey: KJKUJBPQAUQFTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-芘甲醛 在 吡啶 、 sodium tetrahydroborate 、 氯化亚砜 作用下， 以 四氢呋喃 、 二氯甲烷 、 苯 为溶剂， 生成 N,N-diethyl-1-pyrenylmethylamine
  参考文献：
  名称：

  （1-P烯基甲基）氨基醇，一类新型的抗肿瘤DNA嵌入剂。发现和初始胺侧链结构活性研究。

  摘要：

  在这项工作中研究的一系列1-吡啶基甲胺中，研究了结构，与DNA的相互作用以及鼠类抗肿瘤活性之间的关系。结合研究表明，所有这些1-pyrenylmethylamine衍生物都通过嵌入在一定程度上与DNA结合。由于静电相互作用，侧链中额外碱性胺基的存在增强了DNA的结合。那些仅包含单一碱性苄基胺的化合物与DNA的结合类似。仅存在庞大的侧链似乎会减少所检测化合物中的DNA相互作用。尽管对于（1-苯甲基甲基）氨基醇具有抗肿瘤活性，但是该系列中有用的抗肿瘤活性限于带有2-氨基-1，3-丙二醇型侧链的同类物。这些衍生物与DNA适度结合。DNA结合是该系列抗肿瘤活性的必要但不充分的标准。另外，在活性化合物组中，DNA结合的强度与抗肿瘤活性不相关。三种相关的2-[（（芳基甲基）氨基] -1,3-丙二醇衍生物（AMAPs）[crisnatol（770U82），773U82和502U83]目前正在作为潜在的抗肿瘤药物进行临床试验。

  DOI：

  10.1021/jm00171a012

文献信息

• Chemical sensors with non-covalent surface modification of graphene
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：US11079371B2

  公开（公告）日：2021-08-03

  Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.

  本实施例涉及化学传感器、包括化学传感器的设备和系统以及相关方法。在一个实施例中，包括一种医疗设备。该医疗设备可包括石墨烯变容器。石墨烯变容器可以包括石墨烯层和通过π-π堆叠相互作用布置在石墨烯层外表面的自组装单层。自组装单层的 Langmuir theta 值至少为 0.9。自组装单层可包括多环芳香烃、四苯基卟啉或其衍生物、金属四苯基卟啉或芳香环糊精。本文还包括其他实施例。
• BAIR, KENNETH W.;TUTTLE, RICHARD L.;KNICK, VINCENT C.;CORY, MICHAEL;MCKEE+, J. MED. CHEM., 33,(1990) N, C. 2385-2393
  作者：BAIR, KENNETH W.、TUTTLE, RICHARD L.、KNICK, VINCENT C.、CORY, MICHAEL、MCKEE+

  DOI：——

  日期：——
• CHEMICAL SENSORS WITH NON-COVALENT SURFACE MODIFICATION OF GRAPHENE
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：US20190257825A1

  公开（公告）日：2019-08-22

  Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.
• [EN] RAPID PURIFICATION BY POLYAROMATIC QUENCH REAGENTS<br/>[FR] PURIFICATION RAPIDE PAR REACTIFS DE REFROIDISSEMENT BRUSQUE POLYAROMATIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2000039055A1

  公开（公告）日：2000-07-06

  Novel polyaromatic hydrocarbon quenching reagents of Formula (I), wherein: P is a polyaromatic hydrocarbon of low chemical reactivity which is soluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers or dendritic linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.
• [(1-Pyrenylmethyl)amino] alcohols, a new class of antitumor DNA intercalators. Discovery and initial amine side chain structure-activity studies
  作者：Kenneth W. Bair、Richard L. Tuttle、Vincent C. Knick、Michael Cory、David D. McKee

  DOI：10.1021/jm00171a012

  日期：1990.9

  additional basic amine groups in the side chain enhances DNA binding due to electrostatic interactions. Those compounds containing only a single basic benzylic amine bind similarly to DNA. Only the presence of bulky side chains appears to decrease the DNA interactions in the compounds examined. Although antitumor activity is seen for (1-pyrenylmethyl)amino alcohols, useful antitumor activity in the series

  在这项工作中研究的一系列1-吡啶基甲胺中，研究了结构，与DNA的相互作用以及鼠类抗肿瘤活性之间的关系。结合研究表明，所有这些1-pyrenylmethylamine衍生物都通过嵌入在一定程度上与DNA结合。由于静电相互作用，侧链中额外碱性胺基的存在增强了DNA的结合。那些仅包含单一碱性苄基胺的化合物与DNA的结合类似。仅存在庞大的侧链似乎会减少所检测化合物中的DNA相互作用。尽管对于（1-苯甲基甲基）氨基醇具有抗肿瘤活性，但是该系列中有用的抗肿瘤活性限于带有2-氨基-1，3-丙二醇型侧链的同类物。这些衍生物与DNA适度结合。DNA结合是该系列抗肿瘤活性的必要但不充分的标准。另外，在活性化合物组中，DNA结合的强度与抗肿瘤活性不相关。三种相关的2-[（（芳基甲基）氨基] -1,3-丙二醇衍生物（AMAPs）[crisnatol（770U82），773U82和502U83]目前正在作为潜在的抗肿瘤药物进行临床试验。