(S)-5-Oxo-pyrrolidine-2-carboxylic acid [1-(2-chloro-phenyl)-eth-(E)-ylidene]-hydrazide | 133661-76-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-5-Oxo-pyrrolidine-2-carboxylic acid [1-(2-chloro-phenyl)-eth-(E)-ylidene]-hydrazide
• 英文别名: (E)-5-Oxo-L-proline (1-(2-chlorophenyl)ethylidene)hydrazide hydrate；(2S)-N-[(E)-1-(2-chlorophenyl)ethylideneamino]-5-oxopyrrolidine-2-carboxamide
• CAS: 133661-76-4
• 化学式: C₁₃H₁₄ClN₃O₂
• 分子量: 279.726
• InChiKey: UABBEGSYSQJPTF-AXLKIAQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  70.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻氯苯乙酮 、 5-氧代-L-脯氨酰肼 以 乙醇 为溶剂， 反应 3.0h， 生成 (S)-5-Oxo-pyrrolidine-2-carboxylic acid [1-(2-chloro-phenyl)-eth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  Antihypertensive hydrazidones: α-aminoacylated 2-chlorobenzylidene hydrazines

  摘要：

  Hydrazides of amino acids and acylamino acids were condensed with 2-chlorobenzaldehyde or 2-chloroacetophenone. The hydrazidones obtained exhibited antihypertensive activity. In a few cases the activities were similar or higher than those of the reference compounds.

  DOI：

  10.1016/0223-5234(94)90064-7

文献信息

• Antihypertensive hydrazidones: α-aminoacylated 2-chlorobenzylidene hydrazines
  作者：C Cavé、H Galons、M Miocque、P Rinjard、G Tran、P Binet

  DOI：10.1016/0223-5234(94)90064-7

  日期：1994.1

  Hydrazides of amino acids and acylamino acids were condensed with 2-chlorobenzaldehyde or 2-chloroacetophenone. The hydrazidones obtained exhibited antihypertensive activity. In a few cases the activities were similar or higher than those of the reference compounds.