5,6-二氟吡啶-2-甲酸 | 851386-38-4

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5,6-二氟吡啶-2-甲酸
• 英文名称: 5,6-difluoropyridine-2-carboxylic Acid
• CAS: 851386-38-4
• 化学式: C₆H₃F₂NO₂
• mdl: MFCD09031175
• 分子量: 159.09
• InChiKey: NWMYBARTEFULTJ-UHFFFAOYSA-N

物化性质

• 熔点：
  161-162 °C
• 沸点：
  291 °C
• 密度：
  1.535
• 闪点：
  130 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• AZEPINONE DERIVATIVES
  申请人：Okamoto Osamu

  公开号：US20110212891A1

  公开（公告）日：2011-09-01

  The present invention relates to a compound represented by formula (I): wherein R 1 represents a hydrogen atom or the like; R 2 and R 3 represent a hydrogen atom or the like; R 4 is a group represented by (II) R 5 represents a phenyl group which may be substituted with a halogen or the like; m is an integer of from 1 to 3; and p is an integer of from 0 to 4; or a pharmaceutically acceptable salt thereof.

  本发明涉及一种由以下式（I）表示的化合物：其中R1代表氢原子或类似物；R2和R3代表氢原子或类似物；R4是由（II）表示的基团；R5代表可能被卤素或类似物取代的苯基；m为1至3的整数；p为0至4的整数；或其药学上可接受的盐。
• [EN] METAL COMPLEXES WITH DIBENZO[F,H]QUINOXALINES<br/>[FR] COMPLEXES MÉTALLIQUES COMPRENANT DES DIBENZO[F,H]QUINOXALINES
  申请人：BASF SE

  公开号：WO2013104649A1

  公开（公告）日：2013-07-18

  This invention relates to electroluminescent metal complexes of the formula electronic devices comprising the metal complexes and their use in electronic devices, especially organic light emitting diodes (OLEDs). The metal complexes of formula (I) show high emission efficiency, excellent vaporizability, thermal stability, processing stability, high charge carrier mobilities, low turn-on voltage and high temperature stability of the emission color.

  该发明涉及公式为电致发光金属配合物的电子器件，包括金属配合物及其在电子器件中的应用，特别是有机发光二极管（OLEDs）。公式（I）的金属配合物显示出高发射效率、优异的蒸发性、热稳定性、加工稳定性、高载流子迁移率、低开启电压和发射颜色的高温稳定性。
• [EN] BENZODIAZEPIN-2-ON DERIVATIVES<br/>[FR] DÉRIVÉS DE BENZODIAZÉPIN-2-ONE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010084979A1

  公开（公告）日：2010-07-29

  The present invention relates to a compound represented by the formula(I):wherein R1 represents a hydrogen atom or the like;R2 represents lower alkyl or the like;R3 and R4 represent lower alkyl or the like;R5 represents phenyl or the like;R6 represents a hydrogen atom or the like;m is an integer of from 0 to 2;p is an integer of from 1 to 4; and q is an integer of from 1 to 5, or a pharmaceutical acceptable saltthereof, and a DGAT 1 inhibitor comprising the compound.

  本发明涉及一种由下式(I)表示的化合物：其中R1代表氢原子或类似物；R2代表较低的烷基或类似物；R3和R4代表较低的烷基或类似物；R5代表苯基或类似物；R6代表氢原子或类似物；m为0至2的整数；p为1至4的整数；q为1至5的整数，或其药用可接受盐，以及包括该化合物的DGAT 1抑制剂。
• [EN] SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE<br/>[FR] DERIVES D'ALKYLAMINE SUBSTITUES ET METHODES D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2002066470A1

  公开（公告）日：2002-08-29

  Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的杂环化合物对于预防和治疗由血管生成介导的疾病等疾病有效。本发明涵盖了新的化合物、类似物、前药和药学上可接受的衍生物、药物组成物以及预防和治疗癌症等疾病和其他疾病或病况的方法。该发明还涉及制备这种化合物的过程以及在这种过程中有用的中间体。
• [EN] SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF<br/>[FR] DERIVES SUBSTITUES D'AMIDE 2-ALKYLAMINE NICOTINIQUE ET UTILISATIONS ASSOCIEES
  申请人：AMGEN INC

  公开号：WO2004007458A1

  公开（公告）日：2004-01-22

  Selected amines of Formula XIII, which are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的十三号化合物，对于预防和治疗疾病，如介导血管生成的疾病具有有效性。该发明包括新的化合物、类似物、前药和药学上可接受的盐，药物组合物以及用于预防和治疗癌症等疾病和其他病症或状况的方法。该发明还涉及制造这些化合物的过程以及在这些过程中有用的中间体。