2,3,4,5-Tetrahydroxyhexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2,3,4,5-Tetrahydroxyhexanoic acid
• 化学式: C₆H₁₂O₆
• 分子量: 180.16
• InChiKey: NBFWIISVIFCMDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF
  申请人：President and Fellows of Harvard College

  公开号：US20150307444A1

  公开（公告）日：2015-10-29

  HDAC inhibitors of the general formula (I) and (II) and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone deacetylases or other deacetylases, and thus are useful for the treatment of various diseases and disorders associated with acetylase/deacetylase activity as described herein (e.g., cancer). In certain embodiments, the compounds of the invention selectively target either a class or isoform of the HDAC family. Another aspect of the invention provides an assay for determining the inhibitory effect of a test compound on an HDAC protein comprising: incubating the HDAC protein with a substrate of general formula (IIIc) in the presence of a test compound; and determining the activity of the HDAC protein.

  本发明提供的通式（I）和（II）的HDAC抑制剂及其药学上可接受的盐，作为组蛋白去乙酰化酶或其他去乙酰化酶的抑制剂，因此可用于治疗与去乙酰化酶活性相关的各种疾病和障碍，如本文所述（例如癌症）。在某些实施例中，本发明的化合物有选择性地靶向HDAC家族的某个类别或亚型。本发明的另一方面提供了一种用于确定试验化合物对HDAC蛋白的抑制作用的测定方法，包括：在试验化合物的存在下，将HDAC蛋白与通式（IIIc）的底物孵育，并确定HDAC蛋白的活性。
• Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof
  申请人：Novartis AG

  公开号：US10081697B2

  公开（公告）日：2018-09-25

  The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

  本发明提供了一种亲水聚二有机硅氧烷乙烯基交联剂，它包括(1)聚二有机硅氧烷聚合物链，该链由二甲基硅氧烷单元和亲水硅氧烷单元组成，每个二甲基硅氧烷单元具有一个甲基取代基和一个具有二至六个羟基的单价C4-C40有机基取代基，其中亲水硅氧烷单元与二甲基硅氧烷单元的摩尔比为约0.035至约0.15，以及(2)两个末端(甲基)丙烯酰基。亲水性聚二有机硅氧烷乙烯基交联剂的平均分子量为约 3000 道尔顿至约 80000 道尔顿。本发明还涉及一种硅酮水凝胶隐形眼镜，它包括由本发明的亲水聚二有机硅氧烷乙烯基交联剂衍生的重复单元。
• Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo
  申请人：ENGENE, INC.

  公开号：US10456481B2

  公开（公告）日：2019-10-29

  Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.

  本文提供了壳聚糖衍生物纳米粒子，包括用阳离子氨基酸和亲水多元醇官能化的壳聚糖；以及制造和使用这种纳米粒子的方法，例如用于体内基因递送。
• Silicone hydrogel contact lenses
  申请人：Alcon Inc.

  公开号：US10875967B2

  公开（公告）日：2020-12-29

  The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

  本发明一般涉及具有相对较高透氧率、相对较高平衡水含量和相对较低弹性模量的固有可湿性硅水凝胶隐形眼镜。本发明还涉及制作这种固有可湿性硅水凝胶隐形眼镜的方法。
• DUALLY DERIVATIZED CHITOSAN NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME FOR GENE TRANSFER IN VIVO
  申请人：Engene, Inc.

  公开号：EP3049473B1

  公开（公告）日：2021-09-22