2(5H)-Furanone, 3,4-dichloro-5-(4-methoxyphenoxy)- | 647831-99-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2(5H)-Furanone, 3,4-dichloro-5-(4-methoxyphenoxy)-
• 英文别名: 3,4-dichloro-2-(4-methoxyphenoxy)-2H-furan-5-one
• CAS: 647831-99-0
• 化学式: C₁₁H₈Cl₂O₄
• 分子量: 275.088
• InChiKey: FCEXMCMIAZJEPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基苯酚 、 5-methoxycarbonyloxy-3,4-dichloro-5H-furan-2-one 在 cesium fluoride 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以91%的产率得到2(5H)-Furanone, 3,4-dichloro-5-(4-methoxyphenoxy)-
  参考文献：
  名称：

  Further Utilization of Mucohalic Acids:  Palladium-Free, Regioselective Etherification and Amination of α,β-Dihalo γ-Methoxycarbonyloxy and γ-Acetoxy Butenolides

  摘要：

  [GRAPHICS]Palladium-free etherification and amination of mucohalic acid methyl carbonates le (3,4-dichloro-5-methoxycarbonyloxy-5H-furan-2-one) and 1f (3,4-dibromo-5-methoxycarbonyloxy-5H-furan-2-one) and mucochloric acid acetate 1h (3,4-dichloro-5-acetoxy-5H-furan-2-one) was achieved to afford gamma-functionalized alpha,beta-unsaturated gamma-butyrolactones in good to excellent yield.

  DOI：

  10.1021/ol035994n

文献信息

• Preparation of substituted butenolides via palladium-free etherification and amination of masked mucohalic acids
  申请人：Blazecka Garth Peter

  公开号：US20050059831A1

  公开（公告）日：2005-03-17

  Methods and materials for preparing 4-substituted-2-buten-4-olides are disclosed. The methods include reacting a masked mucohalic acid with a primary or secondary amine or with an arylol in the presence of a base. Unlike existing processes, the disclosed methods do not require the use of palladium, which make them well suited for preparing intermediates in drug syntheses.

  公开了制备4-取代-2-丁烯-4-醇内酯的方法和材料。该方法包括在碱存在下将掩蔽的黏膜酸与一级或二级胺或芳基醇反应。与现有的方法不同，公开的方法不需要使用钯，这使它们非常适合用于制备药物合成中间体。
• Chlorophyll and its derivatives for cancer photodynamic therapy
  申请人：Hsu Yih-Chih

  公开号：US20050222117A1

  公开（公告）日：2005-10-06

  The present invention relates to a method for treating liver cancer or oral cancer through photodynamic therapy, comprising administrating a subject in need thereof an effective amount of formula I, formula □, formula III or formula IV, which could release reactive oxygen species to inhibit the growth of cancer cells, which comprise with formulas as described in the specification, wherein R1 is an alkyl or an aldehyde with carbon atoms no more than 2; the cancer is liver cancer or oral cancer.

  本发明涉及一种通过光动力疗法治疗肝癌或口腔癌的方法，包括向有需要的受试者施用有效量的可释放活性氧以抑制癌细胞生长的式I、式□、式III或式IV，其包括如说明书所述的式子，其中R1为碳原子数不超过2的烷基或醛；癌症为肝癌或口腔癌。
• [EN] PREPARATION OF SUBSTITUTED BUTENOLIDES VIA PALLADIUM-FREE ETHERIFICATION AND AMINATION OF MASKED MUCOHALIC ACIDS<br/>[FR] PREPARATION DE BUTENOLIDES SUBSTITUES PAR ETHERIFICATION SANS PALLADIUM ET AMINATION D'ACIDES MUCOHALIQUES MASQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2005026141A2

  公开（公告）日：2005-03-24

  Methods and materials for preparing 4-substituted-2-buten-4-olidos are disclosed. The methods include reacting a masked mucohalic acid with a primary or secondary amine or with an arylol in the presence of a base. Unlike existing processes, the disclosed methods do not require the use of palladium, which make them well suited for preparing intermediates in drug syntheses.
• Further Utilization of Mucohalic Acids:  Palladium-Free, Regioselective Etherification and Amination of α,β-Dihalo γ-Methoxycarbonyloxy and γ-Acetoxy Butenolides
  作者：Peter G. Blazecka、Daniel Belmont、Tim Curran、Derek Pflum、Ji Zhang

  DOI：10.1021/ol035994n

  日期：2003.12.1

  [GRAPHICS]Palladium-free etherification and amination of mucohalic acid methyl carbonates le (3,4-dichloro-5-methoxycarbonyloxy-5H-furan-2-one) and 1f (3,4-dibromo-5-methoxycarbonyloxy-5H-furan-2-one) and mucochloric acid acetate 1h (3,4-dichloro-5-acetoxy-5H-furan-2-one) was achieved to afford gamma-functionalized alpha,beta-unsaturated gamma-butyrolactones in good to excellent yield.