The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthama and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients.
Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below:
wherein R1=H or OCH
3
; R
2
═CH
3
or CHO; R
3
═H or OCH
3
; R
4
═H or OCH
3
Herbal route for the isolation of compound of general formula 1 from the bark of plant
Murraya Koenigii
and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.
本发明涉及一种治疗支气管哮喘和慢性阻塞性肺疾病(
COPD)的方法,包括向患有哮喘和
COPD的患者施用有效剂量的
咔唑衍
生物或其盐,可选地与药学上可接受的赋形剂一起。通用式1的化合物的结构式,作为
磷酸二酯酶-4(PDE-4)酶
抑制剂,信号分子
抑制剂,用于治疗哮喘和哮喘相关疾病,如下所示:其中R1=H或O ;R2=
CH3或CHO;R3=H或O ;R4=H或O 。从植物Murraya Koenigii的树皮中分离通用式1化合物的草药途径以及从基本化合物(如
香草醛)制备这类化合物的
化学途径也已报道。