Danatrol | 17230-88-5

• 物质功能分类: 原料药 - 激素及调节内分泌功能类药 - 雄激素及同化激素类药
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Danatrol
• 英文别名: 17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-ol
• CAS: 17230-88-5
• 化学式: C₂₂H₂₇NO₂
• mdl: MFCD04108703
• 分子量: 337.5
• InChiKey: POZRVZJJTULAOH-UHFFFAOYSA-N

物化性质

• 熔点：
  224.4-226.80C
• 比旋光度：
  D25 +7.5° (ethanol); D25 +21.9° (chloroform)
• 沸点：
  473.76°C (rough estimate)
• 密度：
  1.0909 (rough estimate)
• 溶解度：
  可溶于乙腈（少许）、氯仿（少许）、乙醇（少许）、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S36
• 危险类别码：
  R20/21/22,R63
• WGK Germany：
  3
• 海关编码：
  2937290014
• RTECS号：
  TU4157070

SDS

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Section 1. Chemical Product and Company Identification
Danazol
Common Name/
Trade Name
Danazol

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Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention if irritation occurs.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation Not available.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if
symptoms appear.
Serious Ingestion Not available.

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Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
Products of Combustion These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances Non-flammable in presence of shocks.
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
Slightly explosive in presence of open flames and sparks.
of Various Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Not available.
Special Remarks on
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
Hazards explosion hazard.

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Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Danazol

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Section 7. Handling and Storage
Precautions Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,
evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not
breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the
container or the label.
Storage Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in
light-resistant containers.

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Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.

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Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Solid crystalline powder.) Odor Not available.
Not available.
Taste
Molecular Weight 337.46 g/mole
White to yellowish.
Color
Not applicable.
pH (1% soln/water)
Boiling Point Not available.
Melting Point Decomposition temperature: 225°C (437°F)
Critical Temperature Not available.
Specific Gravity Not available.
Not applicable.
Vapor Pressure
Vapor Density Not available.
Not available.
Volatility
Odor Threshold Not available.
Water/Oil Dist. Coeff. Not available.
Ionicity (in Water) Not available.
Dispersion Properties See solubility in water, acetone.
Solubility Soluble in acetone.
Insoluble in cold water.

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Section 10. Stability and Reactivity Data
Stability The product is stable.
Instability Temperature Not available.
Conditions of Instability Excess heat, dust generation
Incompatibility with various Not available.
substances
Danazol
Corrosivity Not available.
Special Remarks on Sensitive to light.
Reactivity
Special Remarks on Not available.
Corrosivity
Polymerization Will not occur.

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Section 11. Toxicological Information
Routes of Entry Inhalation. Ingestion.
Toxicity to Animals Acute oral toxicity (LD50): 4830 mg/kg [Mouse].
Chronic Effects on Humans TERATOGENIC EFFECTS: Classified POSSIBLE for human.
DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male
[POSSIBLE].
May cause damage to the following organs: kidneys, the reproductive system, liver, pituitary gland.
Other Toxic Effects on Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on May cause adverse reproductive effects and birth defects (teratogenic).
Chronic Effects on Humans May cause cancer.
May affect genetic material (mutagenic)
Special Remarks on other
Potential Health Effects:
Toxic Effects on Humans
Skin: May cause skin irritaiton.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting, constipation, and rarely pancreatitis.
May cause Thromboembolism, thrombotic aand threombophlebitic events, muscle cramps or spasms, or pains,
joint pain, joint lockup, and joint swelling, pain in back, neck, or extremities and rarely carpal tunnel syndrome,
androgen-like effects in women (weight gain, acne, seborrhea, mild hirsutism, emema, hair loss, voice change,
hypertrophy), menstrual disturbances (spotting, amenorrhea), vaginal dryness, reduction in breast size,
hypertrophy of the clitoris(rare)),flushing, sweating. May affect the liver (hepatic dysfunction, jaundice, hepatitis,
hepatic adenoma), allergic Dermatitis or skin rashes, behavior/nervous system (CNS effects: headache,
nervousness, emotional lability, dizziness, fainting, depression, fatigue, sleep disorders, tremor, paresthesias,
weakness, visual disturbances, benign intracranial hypertension, anxiety, chills, changes in appetite; Perpherial
Nervous system effects: Spastic paralysis), urinary system (hematuria), blood (leukocytosis or polycythemia,
eosinophilia, thrombocytopenia). Other symptoms may include elevation in blood pressure, bleeding gums, fever,
pelvic pain, nipple discharge.

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Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The product itself and its products of degradation are not toxic.
of Biodegradation
Special Remarks on the Not available.
Products of Biodegradation
Danazol

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Section 13. Disposal Considerations
Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental
control regulations.

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Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
California prop. 65: This product contains the following ingredients for which the State of California has found to
Federal and State
cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Danazol
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: Danazol
Massachusetts RTK: Danazol
California
California prop. 65: This product contains the following ingredients for which the State of California has found
Proposition 65
to cause birth defects which would require a warning under the statute: Danazol
Warnings
Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC) R40- Possible risks of irreversible S2- Keep out of the reach of children.
effects. S36/37- Wear suitable protective clothing and
R62- Possible risk of impaired fertility. gloves.
R63- Possible risk of harm to the
unborn child.
Health Hazard
HMIS (U.S.A.) 1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
Danazol
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

达那唑（Danazol）简介

达那唑是一种用于治疗子宫内膜异位症、乳腺小叶增生、遗传性血管性水肿及其他疾病的药物，主要通过口服给药。

不良反应

达那唑的主要不良反应包括痤疮、水肿、多毛、声粗、乳房变小、体重增加、皮肤或毛发油腻感、头痛以及肝功能障碍等。大多数女性会出现闭经现象，少数人可能出现不规则阴道出血。

药理作用

达那唑是一种合成的17α-乙炔睾酮衍生物，属于弱雄激素类药物，没有孕激素和雌激素活性。它具有促性腺激素抑制作用，并兼有蛋白质同化及抗孕激素作用。该药物通过作用于下丘脑-垂体-卵巢轴，抑制促性腺激素的分泌与释放，从而减少卵泡刺激素和黄体生成素的释放；直接抑制卵巢甾体激素的生成，使体内雌激素水平下降，进而抑制子宫内膜及异位子宫内膜组织生长，使其失活萎缩，导致不排卵及闭经。这种作用可持续6～8个月。此外，达那唑还能消除纤维性乳腺炎结节、减轻疼痛和触痛，但可能诱发月经失调或闭经，这与其减少雌激素有关。同时，它还能提高血清C1酯酶抑制物水平，导致补体系统中C4浓度升高。

适应症

达那唑用于治疗子宫内膜异位症、纤维性乳腺炎、男性乳房发育、乳腺痛、痛经、腹痛等病症，还适用于性早熟、原发性血小板减少性紫癜、血友病和Christmas病、遗传性血管性水肿以及系统性红斑狼疮的治疗。

生物活性

达那唑是合成类固醇Ethisterone的衍生物，能够抑制促性腺激素产生，并具有一定的弱雄激素作用。主要用于子宫内膜异位症和自发性血小板减少症的治疗。

文献信息

• SOLUBILIZED FLAVONOID COMPOSITION
  申请人：Technology Investments LC

  公开号：EP3345594B1

  公开（公告）日：2021-11-17
• METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND
  申请人：API Genesis, LLC

  公开号：US20140199391A1

  公开（公告）日：2014-07-17

  The subject invention relates to novel soluble forms of planar ring structured organic compounds including flavonoids, and their production. The invention also includes the use of these novel formulations of planar ring structured organic compounds in the preparation of formulations and products. The invention also relates to a wide variety of applications of the formulations of the invention. The subject invention includes novel soluble forms and various formulations of flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.
• US4837212A
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  公开号：US4837212A

  公开（公告）日：1989-06-06
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  公开（公告）日：2014-01-28
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  公开（公告）日：2017-08-15