3-amino-6-(4-ethylphenyl)pyridazine | 1226165-18-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-amino-6-(4-ethylphenyl)pyridazine
• 英文别名: 6-(4-Ethylphenyl)pyridazin-3-amine
• CAS: 1226165-18-9
• 化学式: C₁₂H₁₃N₃
• 分子量: 199.255
• InChiKey: NQUQGKCKCZMTJB-UHFFFAOYSA-N

物化性质

• 沸点：
  409.4±33.0 °C(Predicted)
• 密度：
  1.130±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-amino-6-(4-ethylphenyl)pyridazine 在 溴 、 碳酸氢钠 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 15.5h， 生成 3-(4-ethylphenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine
  参考文献：
  名称：

  A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

  摘要：

  A facile and efficient synthesis of 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines is reported. The key step for the construction of this novel bicyclic scaffold was the reaction between 3-amino-4-bromopyridazine derivatives and alkylisothiocyanates. The application of this methodology for the synthesis of a small library of thiazolo[4,5-c]pyridazines is also described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.072
• 作为产物：
  描述：

  3-amino-4-bromo-6-(4-ethylphenyl)pyridazine 在 caesium carbonate 、 硫代异氰酸苯酯 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成 3-amino-6-(4-ethylphenyl)pyridazine
  参考文献：
  名称：

  A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

  摘要：

  A facile and efficient synthesis of 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines is reported. The key step for the construction of this novel bicyclic scaffold was the reaction between 3-amino-4-bromopyridazine derivatives and alkylisothiocyanates. The application of this methodology for the synthesis of a small library of thiazolo[4,5-c]pyridazines is also described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.072

文献信息

• A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines
  作者：Alessandro Stella、Steven De Jonghe、Kenneth Segers、Piet Herdewijn

  DOI：10.1016/j.tetlet.2012.11.072

  日期：2013.2

  A facile and efficient synthesis of 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines is reported. The key step for the construction of this novel bicyclic scaffold was the reaction between 3-amino-4-bromopyridazine derivatives and alkylisothiocyanates. The application of this methodology for the synthesis of a small library of thiazolo[4,5-c]pyridazines is also described. (C) 2012 Elsevier Ltd. All rights reserved.