7-[2,6-Dimethyl-8-(2-methyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid | 137767-34-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 7-[2,6-Dimethyl-8-(2-methyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
• 英文别名: 7-[2,6-dimethyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
• CAS: 137767-34-1
• 化学式: C₂₄H₃₈O₆
• 分子量: 422.6
• InChiKey: QLJODMDSTUBWDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-[2,6-Dimethyl-8-(2-methyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid 生成 Lovastatin Hydroxy Acid
  参考文献：
  名称：

  ALBERS-SCHONBERG, G.

  摘要：

  DOI：
• 作为产物：
  描述：

  lovastatin 生成 7-[2,6-Dimethyl-8-(2-methyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
  参考文献：
  名称：

  ALBERS-SCHONBERG, G.

  摘要：

  DOI：

文献信息

• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Ion-exchange filtration of fermentation broth
  申请人：Keri Vilmos

  公开号：US20050003499A1

  公开（公告）日：2005-01-06

  The invention encompasses a process for purifying a fermentation broth by providing a fermentation broth; adjusting the pH of the fermentation broth; isolating a filtrate from the fermentation broth; and passing the filtrate through a cation-exchange resin to obtain a purified filtrate.

  本发明包括一种纯化发酵液的工艺，其方法是：提供发酵液；调节发酵液的 pH 值；从发酵液中分离出滤液；将滤液通过阳离子交换树脂以获得纯化滤液。
• Process for the isolation and purification of mevinolin
  申请人：Keri Vilmos

  公开号：US20060223150A1

  公开（公告）日：2006-10-05

  In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carrying out the dissolving at a pH between about 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.

  一种通过生物质在发酵液中发酵制备甲vinolin的工艺，包括将生物质中的甲vinolin溶解到发酵液中，并将生物质从发酵液中分离出来以获得分离的发酵液，从分离的发酵液中分离甲vinolin，并回收最终产品，其中的改进包括在pH值约为7.5至约10之间的条件下进行溶解，而甲vinolin的分离则在pH值约为4.5至约1之间的条件下进行。
• SUBSTITUTED AZETIDINONE COMPOUNDS, FORMULATIONS AND USES THEREOF FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA
  申请人：Schering Corporation

  公开号：EP1601668B1

  公开（公告）日：2008-08-27
• ADVANCED DRUG DEVELOPMENT AND MANUFACTURING
  申请人：Los Alamos National Security, LLC

  公开号：EP2084519A2

  公开（公告）日：2009-08-05