(2R)-2-[(1S)-1-(4-bromophenyl)-2-nitroethyl]-3-oxo-1H-indene-2-carbonitrile | 1381961-38-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (2R)-2-[(1S)-1-(4-bromophenyl)-2-nitroethyl]-3-oxo-1H-indene-2-carbonitrile
• CAS: 1381961-38-1
• 化学式: C₁₈H₁₃BrN₂O₃
• 分子量: 385.217
• InChiKey: VFYQZTANEGNEAG-WMZOPIPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-bromo-β-nitrostyrene 、 2-Cyano-indan-1-on 在 C₄₃H₄₂F₆N₄O₂S₂ 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 (2R)-2-[(1S)-1-(4-bromophenyl)-2-nitroethyl]-3-oxo-1H-indene-2-carbonitrile 、 2-[1-(4-bromophenyl)-2-nitroethyl]-3-oxo-1H-indene-2-carbonitrile
  参考文献：
  名称：

  Enantio- and diastereoselective Michael addition reactions of α-cyanoketones to nitroalkenes catalyzed by binaphthyl-derived organocatalyst

  摘要：

  The catalytic enantioselective and diastereoselective Michael addition reactions promoted by chiral bifunctional organocatalysts are described. The treatment of alpha-cyanoketones with nitroalkenes under mild reaction conditions afforded the corresponding gamma-niro alpha-cyanoketones with excellent diastereoselectivities (up to syn/anti >99/1) and excellent enantioselectivities (up to 99% ee). (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.095

文献信息

• Enantio- and diastereoselective Michael addition reactions of α-cyanoketones to nitroalkenes catalyzed by binaphthyl-derived organocatalyst
  作者：Hyun Joo Lee、Saet Byeol Woo、Dae Young Kim

  DOI：10.1016/j.tetlet.2012.04.095

  日期：2012.6

  The catalytic enantioselective and diastereoselective Michael addition reactions promoted by chiral bifunctional organocatalysts are described. The treatment of alpha-cyanoketones with nitroalkenes under mild reaction conditions afforded the corresponding gamma-niro alpha-cyanoketones with excellent diastereoselectivities (up to syn/anti >99/1) and excellent enantioselectivities (up to 99% ee). (C) 2012 Elsevier Ltd. All rights reserved.