2,2,2-Trifluoro-1-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,2,2-Trifluoro-1-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)ethanone
• 化学式: C₁₃H₁₁F₃N₂O
• 分子量: 268.23
• InChiKey: RLCXDXCCNYCGRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  36.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS
  申请人：Fondazione Istituto Italiano Di Tecnologia

  公开号：US20210292324A1

  公开（公告）日：2021-09-23

  The present invention relates to compounds of Formula (Ia) or pharmaceutically acceptable salts, hydrates, solvates, clathrates, polymorphs, stereoisomers thereof. It further discloses a pharmaceutical composition comprising the compounds of Formula (Ia) and the use of compounds of Formula (Ib), in particular to modulate CFTR protein or ABC protein activities.