4,6-dimethyl-2-(((6-methyl-2-oxo-2H-chromen-4-yl)methyl)thio)nicotinonitrile | 929440-17-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4,6-dimethyl-2-(((6-methyl-2-oxo-2H-chromen-4-yl)methyl)thio)nicotinonitrile
• 英文别名: 4,6-dimethyl-2-[(6-methyl-2-oxochromen-4-yl)methylsulfanyl]pyridine-3-carbonitrile
• CAS: 929440-17-5
• 化学式: C₁₉H₁₆N₂O₂S
• 分子量: 336.414
• InChiKey: RWWHZYKXPVQOHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4,6-dimethyl-2-(((6-methyl-2-oxo-2H-chromen-4-yl)methyl)thio)nicotinonitrile 在 甲酸 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 7-(4-tert-butylphenyl)-2,9,11-trimethyl-6H-chromeno[4,3-d]thieno[3,2-b:5,4-b']dipyridin-6-one
  参考文献：
  名称：

  Synthesis and properties of 4-(3-aminothieno-[2,3-b]pyridin-2-yl)coumarins

  摘要：

  Substituted 4-[(3-cyanopyridin-2-yl)thiomethyl]coumarins have been synthesized by the alkylation of 2-mercapto-4,6-dimethylnicotinonitrile with 4-chloromethylcoumarins. Substituted 4-(3-amino-thieno[2,3-b]pyridin-2-yl)coumarins have been obtained by a subsequent intramolecular condensation of the methylene and cyano groups. 6H-Chromeno[4,3-d]thieno[3,2-b:5,4-b']dipyridin-6-ones were isolated as a result of the interaction of these compounds with aldehydes, and their aminomethyl derivatives were synthesized.

  DOI：

  10.1007/s10593-012-1083-2
• 作为产物：
  描述：

  4-氯甲基-6-甲基-苯并吡喃-2-酮 、 3-氰基-4,6-二甲基-2-硫基吡啶 在 三乙胺 作用下， 以 乙醇 为溶剂， 以80%的产率得到4,6-dimethyl-2-(((6-methyl-2-oxo-2H-chromen-4-yl)methyl)thio)nicotinonitrile
  参考文献：
  名称：

  Synthesis and properties of 4-(3-aminothieno-[2,3-b]pyridin-2-yl)coumarins

  摘要：

  Substituted 4-[(3-cyanopyridin-2-yl)thiomethyl]coumarins have been synthesized by the alkylation of 2-mercapto-4,6-dimethylnicotinonitrile with 4-chloromethylcoumarins. Substituted 4-(3-amino-thieno[2,3-b]pyridin-2-yl)coumarins have been obtained by a subsequent intramolecular condensation of the methylene and cyano groups. 6H-Chromeno[4,3-d]thieno[3,2-b:5,4-b']dipyridin-6-ones were isolated as a result of the interaction of these compounds with aldehydes, and their aminomethyl derivatives were synthesized.

  DOI：

  10.1007/s10593-012-1083-2

文献信息

• Synthesis and properties of 4-(3-aminothieno-[2,3-b]pyridin-2-yl)coumarins
  作者：S. V. Gorelov、S. P. Bondarenko、M. S. Frasinyuk

  DOI：10.1007/s10593-012-1083-2

  日期：2012.9

  Substituted 4-[(3-cyanopyridin-2-yl)thiomethyl]coumarins have been synthesized by the alkylation of 2-mercapto-4,6-dimethylnicotinonitrile with 4-chloromethylcoumarins. Substituted 4-(3-amino-thieno[2,3-b]pyridin-2-yl)coumarins have been obtained by a subsequent intramolecular condensation of the methylene and cyano groups. 6H-Chromeno[4,3-d]thieno[3,2-b:5,4-b']dipyridin-6-ones were isolated as a result of the interaction of these compounds with aldehydes, and their aminomethyl derivatives were synthesized.