N-cyclohexanecarbonyl-N-methyl-glycine | 85856-47-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-cyclohexanecarbonyl-N-methyl-glycine
• 英文别名: N-Cyclohexancarbonyl-N-methyl-glycin；N-(cyclohexylcarbonyl)-N-methylglycine；2-[cyclohexanecarbonyl(methyl)amino]acetic acid
• CAS: 85856-47-9
• 化学式: C₁₀H₁₇NO₃
• mdl: MFCD09045821
• 分子量: 199.25
• InChiKey: SLZWLHCXGUWSJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  肌氨酸 、 环己甲酰氯 在 sodium hydroxide 作用下， 生成 N-cyclohexanecarbonyl-N-methyl-glycine
  参考文献：
  名称：

  Bernhard, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1937, vol. 248, p. 256,274

  摘要：

  DOI：

文献信息

• BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE
  申请人：Fujita Takashi

  公开号：US20130165446A1

  公开（公告）日：2013-06-27

  The present invention addresses the problem of finding a compound having both PPAR activation activity and angiotensin receptor antagonistic activity. The present invention is a benzo- or pyrido-imidazole derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, or a ester or amide thereof (where A is biphenyl methyl-imidazolyl, biphenyl methyl-benzimidazolyl, or the like, B is divalent benzimidazolyl or the like, C is carboxyl or the like, E is divalent phenyl, naphthyl, or the like, G is a dangling bond, oxygen, or the like, Q is oxygen or sulfur, n is an integer from 1 to 6, p is an integer from 1 to 6, V is a dangling bond, oxygen, or the like, and R is hydrogen, alkyl, or the like).

  本发明解决了寻找既具有PPAR激活活性又具有血管紧张素受体拮抗活性的化合物的问题。本发明是一种由通式（I）表示的苯并或吡啶-咪唑衍生物，其药学上可接受的盐，或其酯或酰胺（其中A是联苯甲基咪唑基，联苯甲基苯并咪唑基或类似物，B是二价苯并咪唑基或类似物，C是羧基或类似物，E是二价苯基，萘基或类似物，G是悬键，氧或类似物，Q是氧或硫，n是从1到6的整数，p是从1到6的整数，V是悬键，氧或类似物，R是氢，烷基或类似物）。
• WRINKLE-PREVENTIVE/AMELIORATING AGENT
  申请人：SHISEIDO COMPANY, LTD.

  公开号：EP1908454A1

  公开（公告）日：2008-04-09

  A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R1 represents hydrogen atom, CH3 group or CH2OH group, R2 and R3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R2 and R3 cannot be hydrogen atom at the same time, or R2 and R3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R1 and R4 are hydrogen atom, it cannot be that one of R2 and R3 is benzyloxycarbonyl group and the other is hydrogen atom.

  一种防皱和改善皱纹的组合物，包含一种或一种以上选自下式（1）所代表的 α-氨基酸衍生物及其盐类的化合物： 其中，R1 代表氢原子、CH3 基团或 CH2OH 基团，R2 和 R3 各自独立地代表氢原子、具有 1 至 4 个碳原子的烷基，但 R2 和 R3 不能同时为氢原子，或者 R2 和 R3 与它们所结合的 N 原子可形成一个总碳数为 4 至 6 的环结构、R4 代表氢原子或碳原子数为 1 至 18 的烷基，其中当 R1 和 R4 为氢原子时，R2 和 R3 不能一个为苄氧羰基，另一个为氢原子。
• BENZO- OR PYRIDO-IMIDAZOLE DERIVATIVE
  申请人：Fujita, Takashi

  公开号：EP2581373A1

  公开（公告）日：2013-04-17

  The present invention addresses the problem of finding a compound having both PPAR activation activity and angiotensin receptor antagonistic activity. The present invention is a benzo- or pyrido-imidazole derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, or a ester or amide thereof (where A is biphenyl methyl-imidazolyl, biphenyl methyl-benzimidazolyl, or the like, B is divalent benzimidazolyl or the like, C is carboxyl or the like, E is divalent phenyl, naphthyl, or the like, G is a dangling bond, oxygen, or the like, Q is oxygen or sulfur, n is an integer from 1 to 6, p is an integer from 1 to 6, V is a dangling bond, oxygen, or the like, and R is hydrogen, alkyl, or the like).

  本发明要解决的问题是找到一种既具有 PPAR 激活活性又具有血管紧张素受体拮抗活性的化合物。本发明是通式（I）代表的苯并咪唑或吡啶咪唑衍生物、其药学上可接受的盐或其酯或酰胺（其中 A 是联苯甲基咪唑基、联苯甲基苯并咪唑基或类似物，B 是二价苯并咪唑基或类似物、C 是羧基或类似物，E 是二价苯基、萘基或类似物，G 是悬键、氧或类似物，Q 是氧或硫，n 是 1 到 6 的整数，p 是 1 到 6 的整数，V 是悬键、氧或类似物，R 是氢、烷基或类似物）。
• WRINKLE-PREVENTING AND IMPROVING COMPOSITION
  申请人：TSUNENAGA Makoto

  公开号：US20100168468A1

  公开（公告）日：2010-07-01

  A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R 1 represents hydrogen atom, CH 3 group or CH 2 OH group, R 2 and R 3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R 2 and R 3 cannot be hydrogen atom at the same time, or R 2 and R 3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R 4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R 1 and R 4 are hydrogen atom, it cannot be that one of R 2 and R 3 is benzyloxycarbonyl group and the other is hydrogen atom.
• Wrinkle-preventing and improving composition
  申请人：Tsunenaga Makoto

  公开号：US20110065794A1

  公开（公告）日：2011-03-17

  A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R 1 represents hydrogen atom, CH 3 group or CH 2 OH group, R 2 and R 3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R 2 and R 3 cannot be hydrogen atom at the same time, or R 2 and R 3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R 4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R 1 and R 4 are hydrogen atom, it cannot be that one of R 2 and R 3 is benzyloxycarbonyl group and the other is hydrogen atom.