2-amino-3-(1H-indol-3-yl)propanal

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-amino-3-(1H-indol-3-yl)propanal
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.23
• InChiKey: SOPHXQXKBAXPAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Arylmethylene substituted N-acyl-beta-amino alcohols
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2018859A1

  公开（公告）日：2009-01-28

  The present invention relates to arylmethylene substituted N-Acyl-β-amino alcohols of the formula I in which Y is selected from the aryl or heteroaryl groups: and R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及式I的芳基亚甲基取代的N-酰基-β-氨基醇 其中 Y 从芳基或杂芳基中选择: 和 R1、R2、R3、R4、R5、Q、X和W的含义如描述中所定义。 根据本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• [EN] PROCESS FOR THE PREPARATION OF 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLIN-3-CARBOXYLIC ACID ESTERS"<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ESTERS DE L'ACIDE 2,3,4,9-TÉTRAHYDRO-1H-BÊTA-CARBOLIN-3-CARBOXYLIQUE
  申请人：ENDURA SPA

  公开号：WO2009103787A1

  公开（公告）日：2009-08-27

  The present invention relates to the process of preparation of 2,3,4,9-tetrahydro- 1 /-/-β-carbolin-3-carboxylic acid esters substituted in position 1 of the general formula (I). in the preferred diastereoisomeric form through a single step starting from tryptophan in racemic form and/or its enantiomers and from 3,4-(methylenedioxy)benzaldehyde.

  本发明涉及一种从色氨酸的外消旋形式和/或其对映体以及3,4-(亚甲二氧基)苯甲醛出发，通过单步法制备1位取代的2,3,4,9-四氢-1H-β-吲哚-3-羧酸酯的过程，其一种首选的对映异构形式。
• [EN] AMINOPIPERIDINE AMIDES, DERIVATIVES, COMPOSITIONS, AND USES RELATED TO CXCR4 MODULATION<br/>[FR] AMIDES D'AMINOPIPÉRIDINE, DÉRIVÉS, COMPOSITIONS ET UTILISATIONS ASSOCIÉES À LA MODULATION DE CXCR4
  申请人：UNIV EMORY

  公开号：WO2021217143A1

  公开（公告）日：2021-10-28

  This disclosure relates to aminopiperidine amides, derivatives, pharmaceutical compositions, and uses related to CXCR4 modulation. In certain embodiments, the aminopiperidine amides are compounds having formula I, salts, derivatives, and prodrugs thereof wherein, R1, R2, and R3 are further defined herein. In certain embodiments, this disclosure contemplates pharmaceutical compositions comprising compounds disclosed herein. In certain embodiments, this disclosure relates to methods of treating or preventing CXCR4 related diseases or conditions by administering an effective amount of a compound disclosed herein to a subject in need thereof.

  本公开涉及氨基哌啶酰胺、衍生物、制药组合物以及与CXCR4调节相关的用途。在某些实施例中，氨基哌啶酰胺是具有公式I，其盐、衍生物和前药的化合物，其中，R1、R2和R3在此进一步定义。在某些实施例中，本公开考虑了包含所述化合物的制药组合物。在某些实施例中，本公开涉及通过向需要治疗或预防与CXCR4相关的疾病或病况的受试者投与所述化合物的有效量来治疗或预防CXCR4相关疾病或病况的方法。
• [EN] CYCLIC PEPTIDE COMPOUNDS AND RELATED METHODS, SALTS AND COMPOSITIONS<br/>[FR] COMPOSÉS DE PEPTIDES CYCLIQUES ET PROCÉDÉS, SELS ET COMPOSITIONS ASSOCIÉS
  申请人：MERCK SHARP & DOHME

  公开号：WO2015172047A1

  公开（公告）日：2015-11-12

  This invention relates to compounds useful in the preparation of lipopeptides and related methods of preparing and using these compounds.

  本发明涉及在制备脂肽和相关方法中有用的化合物，以及制备和使用这些化合物的相关方法。
• Arylmethylene Substituted N-Acyl-Beta-Amino Alcohols
  申请人：WORTMANN Lars

  公开号：US20090082372A1

  公开（公告）日：2009-03-26

  The present invention relates to arylmethylene substituted N-Acyl-β-amino alcohols of the formula I in which Y is selected from the aryl or heteroaryl groups: and R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及公式I的芳基亚甲基取代的N-酰基-β-氨基醇化合物，其中Y选自芳基或杂芳基基团：R1，R2，R3，R4，R5，Q，X和W的含义如描述中所定义。本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。