3-(3-fluorophenyl)thiophene | 189335-93-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3-fluorophenyl)thiophene
• CAS: 189335-93-1
• 化学式: C₁₀H₇FS
• mdl: MFCD02260252
• 分子量: 178.23
• InChiKey: JROQAKHICNOXFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(3-fluorophenyl)thiophene 在 bis-triphenylphosphine-palladium(II) chloride 、 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 methyl 2-(3-(3-fluorophenyl)thiophen-2-yl)-4-fluorobenzoate
  参考文献：
  名称：

  EP3686201

  摘要：

  公开号：

文献信息

• Rhodium-Catalyzed Annulative Coupling of 3-Phenylthiophenes with Alkynes Involving Double C-H Bond Cleavages
  作者：Tomonori Iitsuka、Koji Hirano、Tetsuya Satoh、Masahiro Miura

  DOI：10.1002/chem.201303847

  日期：2014.1.7

  Double CH bond activation took place efficiently upon treatment of 3‐phenylthiophenes with alkynes in the presence of a rhodium catalyst and a copper salt oxidant to form the corresponding naphthothiophene derivatives. Dehydrogenative coupling with alkenes was also found to occur on the phenyl moiety rather than the thiophene ring. These reactions provide straightforward synthetic methods for π‐conjugated

  在铑催化剂和铜盐氧化剂的存在下，用炔烃处理3-苯基噻吩后，有效地进行了双CH键活化，从而形成了相应的萘噻吩衍生物。还发现与烯烃的脱氢偶联发生在苯基部分而不是噻吩环上。这些反应从容易获得的简单结构单元为涉及噻吩单元的π共轭分子提供了简单的合成方法。
• Toothbrush assembly having an environmentally safe polymer battery
  申请人：Colgate-Palmolive Company

  公开号：EP1776894A2

  公开（公告）日：2007-04-25

  A toothbrush assembly, comprising: - a head connected to a handle, said head having at least one cleaning element extending outwardly therefrom; - a powered element provided in at least one of said head and said handle; and - a polymer battery electrically coupled to said powered element to provide power thereto.

  牙刷组件，包括 - 与手柄连接的头部，所述头部至少有一个向外延伸的清洁元件； - 在所述头部和手柄中的至少一个中装有一个供电元件；以及 - 一个聚合物电池，与所述供电元件电连接，为其供电。
• INFLUENZA VIRUS REPLICATION INHIBITOR AND USE THEREOF
  申请人：Sunshine Lake Pharma Co., Ltd.

  公开号：EP3686201A1

  公开（公告）日：2020-07-29

  Disclosed are a compound as shown in formula (I) as an influenza virus replication inhibitor and a preparation method therefor, a pharmaceutical composition comprising the compound and the use of the compound and pharmaceutical composition thereof in the treatment of influenza.

  公开了作为流感病毒复制抑制剂的式 (I) 所示化合物及其制备方法、包含该化合物的药物组合物以及该化合物及其药物组合物在治疗流感中的用途。
• Rhodium-Catalyzed Dehydrogenative Coupling of Phenylheteroarenes with Alkynes or Alkenes
  作者：Tomonori Iitsuka、Koji Hirano、Tetsuya Satoh、Masahiro Miura

  DOI：10.1021/acs.joc.5b00155

  日期：2015.3.6

  Benzo-fused tri- to heptacyclic heteroarenes were effectively constructed by the rhodium-catalyzed dehydrogenative coupling of phenylheteroarenes with alkynes. Using alkenes as coupling partners, dehydrogenative alkenylation took place selectively on the phenyl moiety of phenylheteroarenes. Several experiments with deuterium-labeled substrates indicated that double C-H bond cleavages take place even in the reaction with alkenes.
• 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS AND METHODS OF THEIR USE
  申请人：Lexicon Pharmaceuticals, Inc.

  公开号：EP3176159B1

  公开（公告）日：2020-10-21