(2S,3S)-3-[(S)-sec-butyl]-2-methylhex-5-ene-1,3-diol | 1181349-68-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S,3S)-3-[(S)-sec-butyl]-2-methylhex-5-ene-1,3-diol
• 英文别名: (2S,3S)-3-[(2S)-butan-2-yl]-2-methylhex-5-ene-1,3-diol
• CAS: 1181349-68-7
• 化学式: C₁₁H₂₂O₂
• 分子量: 186.294
• InChiKey: LVYLMSFLEOMRPX-DCAQKATOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-{(2R,3S)-3-[(S)-sec-butyl]-3-hydroxy-2-methylhex-5-enyl} (-)-camphorsultam 在 lithium aluminium tetrahydride 作用下， 反应 0.5h， 以70%的产率得到(2S,3S)-3-[(S)-sec-butyl]-2-methylhex-5-ene-1,3-diol
  参考文献：
  名称：

  Stereoselective Synthesis of α-Alkyl-β-keto Imides via Asymmetric Redox C−C Bond Formation between α-Alkyl-α-diazocarbonyl Compounds and Aldehydes

  摘要：

  Asymmetric redox C-C bond formation between alpha-alkyl-alpha-diazocarbonyl compounds and aldehydes was developed as a practical and general method for the construction of alpha-alkyl-beta-keto imides having a chiral nonracemic tertiary stereogenic center.

  DOI：

  10.1021/ja903500w

文献信息

• Stereoselective Synthesis of α-Alkyl-β-keto Imides via Asymmetric Redox C−C Bond Formation between α-Alkyl-α-diazocarbonyl Compounds and Aldehydes
  作者：Takuya Hashimoto、Hisashi Miyamoto、Yuki Naganawa、Keiji Maruoka

  DOI：10.1021/ja903500w

  日期：2009.8.19

  Asymmetric redox C-C bond formation between alpha-alkyl-alpha-diazocarbonyl compounds and aldehydes was developed as a practical and general method for the construction of alpha-alkyl-beta-keto imides having a chiral nonracemic tertiary stereogenic center.