2-amino-3-(tert-butyldisulfanyl)propanoic acid | 4151-65-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-3-(tert-butyldisulfanyl)propanoic acid
• 英文别名: 2-azaniumyl-3-(tert-butyldisulfanyl)propanoate
• CAS: 4151-65-9
• 化学式: C₇H₁₅NO₂S₂
• mdl: MFCD03547896
• 分子量: 209.334
• InChiKey: TWMBHZTWEDJDRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-amino-3-(tert-butyldisulfanyl)propanoic acid 在 potassium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 6.75h， 生成 tert-butyl 4-(3-(tert-butyldisulfanyl)-2-(isobutoxycarbonylamino)propanamido)piperidine-1-carboxylate
  参考文献：
  名称：

  FUNCTIONALLY-MODIFIED OLIGONUCLEOTIDES AND SUBUNITS THEREOF

  摘要：

  提供了包含修改的亚单位间连接和/或修改的3'和/或5'-末端基团的功能修饰寡核苷酸类似物。所公开的化合物对于治疗需要抑制蛋白质表达或纠正异常mRNA剪接产物以产生有益治疗效果的疾病是有用的。

  公开号：

  US20140330006A1

文献信息

• [EN] RAS BINDING PEPTIDES AND METHODS OF USE<br/>[FR] PEPTIDES DE LIAISON À RAS ET MÉTHODES D'UTILISATION
  申请人：RA PHARMACEUTICALS INC

  公开号：WO2017181061A1

  公开（公告）日：2017-10-19

  The present invention provides Ras modulators including inhibitors and/or antagonists of Ras, Ras binding, and Ras-dependent cell signaling activity. Also provided are methods of utilizing the Ras modulators as therapeutics.

  本发明提供了Ras调节剂，包括Ras的抑制剂和/或拮抗剂，以及Ras结合和Ras依赖的细胞信号活性。还提供了利用这些Ras调节剂作为治疗药物的方法。
• [EN] HYDROGELS WITH BIODEGRADABLE CROSSLINKING<br/>[FR] HYDROGELS À RÉTICULATION BIODÉGRADABLE
  申请人：PROLYNX LLC

  公开号：WO2013036847A1

  公开（公告）日：2013-03-14

  Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.

  描述了在适当的pH和温度条件下通过交联化合物裂解的水凝胶。这些水凝胶可用于传递各种药剂，如药物。该发明提供了在暴露于生理条件下会非酶催化降解为较小可溶性组分的水凝胶，以及制备它们的方法。这些水凝胶是由在生理条件下发生消除反应的交联剂制备而成，从而将交联剂从水凝胶的骨架中裂解出来。该发明还涉及交联剂本身以及形成该发明的水凝胶的中间体。根据该发明的方法制备的可生物降解水凝胶可用于各种领域，包括生物医学工程、吸收材料以及作为药物传递的载体。
• HYDROGELS WITH BIODEGRADABLE CROSSLINKING
  申请人：ProLynx LLC

  公开号：US20170312368A1

  公开（公告）日：2017-11-02

  Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

  描述了在适当的pH和温度条件下，由于交联化合物通过消除反应而降解的水凝胶。这些水凝胶可以用于输送各种药剂，如药物。
• Pyruvate derivatives
  申请人：——

  公开号：US20030013656A1

  公开（公告）日：2003-01-16

  Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.

  某些已知和新颖的丙酮酸衍生物在恢复或保护已经遭受氧气剥夺的氧化能力细胞的代谢完整性方面特别活跃。这些由丙酮酸衍生的化合物包括但不限于肟、酰胺、丙酮酸类似物、改性丙酮酸类似物、丙酮酸酯（例如，聚醇丙酮酸酯、丙酮酸硫酯、甘油丙酮酸酯和二羟基丙酮酸酯）。这些丙酮酸衍生物（包括单重构体、单立体异构体和重构体和/或立体异构体混合物以及其药用可接受的盐）可用于制造用于治疗多种由氧化应激特征的疾病的药物组合物。
• Compositions for use in golf balls
  申请人：Bulpett A. David

  公开号：US20050245652A1

  公开（公告）日：2005-11-03

  A golf ball comprises a core, an outer cover layer, and, optionally, an intermediate layer disposed between the core and the outer cover layer. The outer cover layer may comprise a polyurethane or polyurea composition. At least one portion of the golf ball comprises a composition that enhances physical properties and/or performance characteristics (e.g., coefficient of restitution) of the golf ball. Preferably, the coefficient of restitution of the core is 0.8 or greater.

  高尔夫球由内核、外覆盖层和可选的中间层组成，外覆盖层可以包括聚氨酯或聚脲组成。高尔夫球的至少一部分包含一种增强物理特性和/或性能特征（例如反弹系数）的组合物。最好，内核的反弹系数为0.8或更高。