Tryptophyl-tyrosine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tryptophyl-tyrosine
• 英文别名: Tryptophanyltyrosin；2-[[2-azaniumyl-3-(1H-indol-3-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoate
• 化学式: C₂₀H₂₁N₃O₄
• 分子量: 367.404
• InChiKey: TYYLDKGBCJGJGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Sodium orthovanadate 、 Tryptophyl-tyrosine 在 KCl 、 N(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Tracey, Alan S.; Jaswai, Jaswinder S.; Nxumalo, Fikile, Canadian Journal of Chemistry, 1995, vol. 73, p. 489 - 498

  摘要：

  DOI：

文献信息

• ADDITIVE FOR UNDIFFERENTIATION MAINTAINING MEDIUM
  申请人：Ajinomoto Co., Inc.

  公开号：EP3604503A1

  公开（公告）日：2020-02-05

  The present invention provides a medium for culturing pluripotency stem cells, containing L-tryptophan or L-tryptophan derivative at a concentration of not less than 176 µM.

  本发明提供了一种培养多能干细胞的培养基，其中含有浓度不低于 176 µM 的 L-色氨酸或 L-色氨酸衍生物。
• Functional mono- and dinuclear peptide complexes featuring chemospecific κS- or η6-coordination of organometallic half-sandwich fragments
  作者：Ralf Stodt、Susan Gencaslan、André Frodl、Claudia Schmidt、William S Sheldrick

  DOI：10.1016/s0020-1693(03)00345-1

  日期：2003.11

  Treatment of the dipeptides H-Tyr-Trp-OH, H-Trp-Tyr-OH, H-Trp-Phe-OH and H-Phe-Tyr-OH with [(T,(6)- cymene)Ru(acetone)(3)].(CF3SO3)(2) (1) in CF3COOH leads to chemospecific eta(6)-coordination in the order of electron-donating ability Trp > Tyr > Phe in respective complexes of the type [(eta(6)-cymene)Ru(eta(6) -dipeptide)](CF3SO3)(2) (3-6) after 24-36 h at 20degreesC. An analogous thermodynamic chemospecificity was also established for the complexes [(eta(5) -Cp*)Ir(eta(6)-dipeptide)](CF3SO3)(2) (7, H-Phe-Trp-OH; 8, H-Phe-Tyr-OH). However, a time-dependent 1H NMR study of the reaction between [(eta(5) -Cp*)Ir(acetone)(3)] (CF3SO3)(2) (2) and H-Tyr-Phe-OH confirms an initial kinetic preference for eta(6)-coordination of the C-terminal arene, as is also apparent from product mixtures obtained after treating 2 with H-Trp-Phe-OH or H-Trp-Tyr-OH for 1-2 d at 50 degreesC. Dinuclear sandwich complexes of the type [(eta(5)-Cp *)Ir(mu(2)-H-Met-X-OH-eta(6)-X:kappa(2)N(M), S)Pt(en)](CF3SO3)(4) (9-11, X = Phe, Tyr, Trp) can be prepared in CF3COOH following initial N-terminal kappa(2)N(M), S chelation of the (en)Pt-II fragment by the methionine residue of the dipeptide. Chemospecific kappaS coordination of the [(eta(5)-Cp *)Ir(dppZ)](2+) fragment in [(eta(5)-Cp*)Ir(dppz) (H-2-HArg-Met-NH2-kappaS)](4+) (12), [(eta(5)-Cp*)Ir(dppz)}(2)(mu-H-2-Met -Met-OH-kappaS:kappaS')](5+) (13) and [(eta(5)-Cp*)Ir(dppz)(mu-H-Gly-Met-OH-kappaS:kappaN(G))Pt(terpy)](4+) (14) affords effective metallointercalators for DNA with binding constants K-b in the range 1.3-3.3 x 10(6) M-1 and marked melting temperature shifts DeltaT(m) of respectively 10.2, 15.2 and 11.2 degreesC. (C) 2003 Elsevier B.V. All rights reserved.
• Tracey, Alan S.; Jaswai, Jaswinder S.; Nxumalo, Fikile, Canadian Journal of Chemistry, 1995, vol. 73, p. 489 - 498
  作者：Tracey, Alan S.、Jaswai, Jaswinder S.、Nxumalo, Fikile、Agnus-Dunne, Sarah J.

  DOI：——

  日期：——