9,14-dihydroxy-octadecanoic acid | 65370-66-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9,14-dihydroxy-octadecanoic acid
• 英文别名: 9,14-Dihydroxy-octadecansaeure；9,14-Dihydroxyoctadecanoic acid
• CAS: 65370-66-3
• 化学式: C₁₈H₃₆O₄
• 分子量: 316.481
• InChiKey: UHSVJNCEYVVOCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9,14-dihydroxy-octadecanoic acid 在 chromium(VI) oxide 、 硫酸 作用下， 以 溶剂黄146 为溶剂， 生成 9,14-Dioxo-octadecanoic acid methyl ester
  参考文献：
  名称：

  一种新的山核桃油中的二羟基酸

  摘要：

  摘要 Peganumharmala 的种子油含有一种以前未知的二羟基酸，其特征是 9,14-二羟基十八烷酸。P.harmala 是第一种发现在其甘油三酯中含有这种非邻位二醇酸 (3.2%) 的高等植物。

  DOI：

  10.1016/0031-9422(71)85084-7
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 铂 作用下， 生成 9,14-dihydroxy-octadecanoic acid
  参考文献：
  名称：

  Isolation and Structure of a Dihydroxyoctadecadienoic Acid from Tung Oil

  摘要：

  DOI：

  10.1021/ja01157a035

文献信息

• UNIFORM FIELD MAGNETIZATION AND TARGETING OF THERAPEUTIC FORMULATIONS
  申请人：The Children's Hospital of Philadelphia

  公开号：EP2512512A1

  公开（公告）日：2012-10-24
• Uniform field magnetization and targeting of therapeutic formulations
  申请人：Levy Robert J.

  公开号：US20090082611A1

  公开（公告）日：2009-03-26

  Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.
• Uniform Field Magnetization and Targeting of Therapeutic Formulations
  申请人：Levy Robert J.

  公开号：US20130011370A1

  公开（公告）日：2013-01-10

  Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.
• PHARMACEUTICAL CARRIERS CAPABLE OF pH DEPENDENT RECONSTITUTION AND METHODS FOR MAKING AND USING SAME
  申请人：PLx Opco Inc.

  公开号：US20220000886A1

  公开（公告）日：2022-01-06

  Disclosed herein are novel drug carriers including a non-aqueous pH dependent release system and a non-aqueous pH dependent reassembly/assembly and reabsorption/absorption system. The carriers are capable of pH dependent release of biologically active agents and assembly or reassembly when the carrier transitions from a low pH environment, to a high pH environment and back to a low pH environment.
• US8562505B2
  申请人：——

  公开号：US8562505B2

  公开（公告）日：2013-10-22