isovaleric acid α-monoglyceride | 64633-18-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: isovaleric acid α-monoglyceride
• 英文别名: (+/-)-glycerol-1-isovalerate；(+/-)-Glycerin-1-isovalerat；3-Isovaleryloxy-propan-1,2-diol；glyceryl-1-monoisovalerate；Glycerol 1-monoisopentanoate；2,3-dihydroxypropyl 3-methylbutanoate
• CAS: 64633-18-7
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: VDUFFSYTQWCYGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  isovaleric acid α-monoglyceride 、 2,2-二甲氧基丙烷 在 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 生成 (RS)-1,2-O-isopropylidene glycerol isovalerate
  参考文献：
  名称：

  Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity

  摘要：

  Fifteen new galactoglycerolipid analogues, in which one or two branched, alicyclic or aromatic acyl chains are linked to 2-O-beta-D-galacto-sylglycerol (6'-position or 1,6' positions), were prepared and tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein-Barr virus early antigen (EBV-EA) activation. All compounds were active in inhibiting the EBV activation promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the branched compounds resulting in the most active glycoglycerolipid analogues of the series. The branched 2-O-[6-O-(3-methylbutanoyl)-beta-D-galactopyranosyll-sn-glyceroI (1a) and the structurally related alicyclic 2-O-[6-O-(2-cyclohexylethanoyl)-beta-D-galactopyranosyl]-sn-glycerol (1d), when tested in an in vivo two-stage carcinogenesis test, exhibited inhibitory effects on mouse skin tumor promotion. (c) 2006 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.07.007
• 作为产物：
  描述：

  3-Methyl-butyric acid (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-[1-hydroxymethyl-2-(3-methyl-butyryloxy)-ethoxy]-tetrahydro-pyran-2-ylmethyl ester 在 Aspergillus oryzae β-galactosidase 作用下， 生成 isovaleric acid α-monoglyceride
  参考文献：
  名称：

  Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity

  摘要：

  Fifteen new galactoglycerolipid analogues, in which one or two branched, alicyclic or aromatic acyl chains are linked to 2-O-beta-D-galacto-sylglycerol (6'-position or 1,6' positions), were prepared and tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein-Barr virus early antigen (EBV-EA) activation. All compounds were active in inhibiting the EBV activation promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the branched compounds resulting in the most active glycoglycerolipid analogues of the series. The branched 2-O-[6-O-(3-methylbutanoyl)-beta-D-galactopyranosyll-sn-glyceroI (1a) and the structurally related alicyclic 2-O-[6-O-(2-cyclohexylethanoyl)-beta-D-galactopyranosyl]-sn-glycerol (1d), when tested in an in vivo two-stage carcinogenesis test, exhibited inhibitory effects on mouse skin tumor promotion. (c) 2006 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.07.007

文献信息

• Single-phase antiperspirant compositions containing solubilized antiperspirant active and silicone elastomer
  申请人：——

  公开号：US20020106340A1

  公开（公告）日：2002-08-08

  Disclosed are antiperspirant and deodorant compositions and corresponding methods of application, wherein the compositions are single-phase systems that comprise a solubilized antiperspirant active, a silicone elastomer and a volatile silicone. These compositions provide improved low residue performance, enhanced stability, and improved cosmetics.

  本发明公开了止汗剂和除臭剂组合物及相应的应用方法，其中组合物为单相体系，由增溶止汗剂活性物质、硅氧烷弹性体和挥发性硅氧烷组成。这些组合物具有更好的低残留性能、更高的稳定性和更佳的美容效果。
• Single-phase antiperspirant compositions containing solubilized antiperspirant active and volatile silicone
  申请人：——

  公开号：US20020110532A1

  公开（公告）日：2002-08-15

  Disclosed are single-phase antiperspirant compositions and corresponding methods of application, wherein the compositions are single-phase systems that comprise a solubilized antiperspirant active, a volatile silicone and selected coupling materials that are substantially free of Si—OH and Si—H functional groups and that have a solubility parameter of from about 7 to about 12, wherein the sum total solubility parameter of the essential components in the composition is from about 9 to about 13. These compositions provide improved low residue performance, enhanced stability, improved efficacy, and/or improved cosmetics.

  本发明公开了单相止汗剂组合物及相应的应用方法，其中组合物为单相体系，包含溶解的止汗剂活性物质、挥发性有机硅以及基本上不含Si-OH和Si-H官能团的精选偶联材料，其溶解度参数约为7至12，其中组合物中主要成分的总溶解度参数约为9至13。这些组合物具有更好的低残留性能、更强的稳定性、更高的功效和/或更好的美容效果。
• Anhydrous liquid antiperspirant emulsions
  申请人：The Procter & Gamble Company

  公开号：US20030026773A1

  公开（公告）日：2003-02-06

  Disclosed are liquid anhydrous antiperspirant emulsions, comprising (a) an external phase containing a non-volatile hydrophobic liquid; and (b) an internal phase containing an antiperspirant active solubilized in a polar solvent; wherein the emulsions have an external to internal phase ratio of at least about 1.25 and a weight ratio of the non-volatile hydrophobic liquid to the combination of antiperspirant active and polar solvent in the internal phase of at least about 0.33. The anhydrous antiperspirant emulsions provide little or no visible residue on the skin and also provide for a smooth, dry, non-sticky, skin-feel during and after application. These emulsions are especially useful when delivered from a roll-on applicator.

  本发明公开了液态无水止汗剂乳液，包括：(a) 外相，内含非挥发性疏水性液体；(b) 内相，内含溶解在极性溶剂中的止汗剂活性物质；其中，乳液的外相与内相之比至少约为 1.25，非挥发性疏水性液体与内相中止汗剂活性物质和极性溶剂组合的重量比至少约为 0.33。无水止汗剂乳液在皮肤上几乎没有可见的残留物，而且在使用过程中和使用后皮肤光滑、干燥、不粘腻。这些乳液在使用滚动涂抹器时特别有用。
• STABLE PRESSURIZED ANTIPERSPIRANT COMPOSITIONS CONTAINING DIMETHYLETHER PROPELLANT AND A LOW POLARITY SOLVENT
  申请人：The Procter & Gamble Company

  公开号：US20030007935A1

  公开（公告）日：2003-01-09

  Disclosed are pressurized antiperspirant compositions comprising (a) a polyol solvent having at least 4 carbon atoms and a hydroxyl group on each of the &agr; and &bgr; carbon atoms of the polyol solvent; (b) solubilized antiperspirant active; (c) dimethylether; (d) a low polarity liquid having a solubility parameter of less than about 8.0, wherein the weight ratio of the dimethylether to low polarity solvent is from about 0.1 to about 2.8 It has been found that these compositions are especially useful in formulating clear or single-phase pressurized antiperspirant compositions that remain stable over prolonged periods and that can be formulated without ethanol or aqueous solvents.

  所公开的加压止汗剂组合物包含(a)多元醇溶剂，该多元醇溶剂具有至少 4 个碳原子，且多元醇溶剂的&agr;和&bgr;碳原子上各有一个羟基；(b)增溶的止汗剂活性物质；(c)二甲醚；(d)溶解度参数小于约 8.0 的低极性液体。0 ，其中二甲基醚与低极性溶剂的重量比为约 0.1 至约 2.8。已发现这些组合物在配制透明或单相加压止汗剂组合物时特别有用，这些组合物在长时间内保持稳定，并且可以在没有乙醇或水性溶剂的情况下配制。
• Metered-dose underarm product and package
  申请人：——

  公开号：US20030213818A1

  公开（公告）日：2003-11-20

  An underarm product and a spray package having a metered-dose valve assembly. The underarm product is contained and pressurized inside of the package. The underarm product being in the form of a liquid or emulsion. The underarm product is an antiperspirant or a deodorant. The underarm product contains a solubilized and/or non-solubilized propellant.

  一种腋下产品和一个具有计量剂量阀组件的喷雾包。腋下产品装在包装内并在包装内加压。腋下产品为液体或乳液形式。腋下产品是止汗剂或除臭剂。腋下产品含有增溶剂和/或非增溶剂推进剂。