5-hydroxy-7-methoxyindan-1-spiro-cyclohexane

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5-hydroxy-7-methoxyindan-1-spiro-cyclohexane
• 英文别名: 5-Hydroxy-7-methoxyindan-1-spiro cyclohexane；7-methoxyspiro[2,3-dihydroindene-1,1'-cyclohexane]-5-ol
• 化学式: C₁₅H₂₀O₂
• 分子量: 232.323
• InChiKey: WIORXPRHJCKWLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 sodium tetrahydroborate 、 lithium hydride 作用下， 以 六甲基磷酰三胺 、 溶剂黄146 为溶剂， 反应 28.0h， 生成 5-hydroxy-7-methoxyindan-1-spiro-cyclohexane
  参考文献：
  名称：

  来自 Cannabis sativa 的 Spiro-indans

  摘要：

  摘要 从大麻（Cannabis sativa）中分离出三个新的螺茚。它们的化学结构是通过光谱方法确定的，并通过与大麻吡喃和异大麻二酚的化学相关性确定。发现它们是7-羟基-5-甲氧基茚满-1-螺环己烷、其异构体5-羟基-7-甲氧基茚满-1-螺环己烷和5,7-二羟基茚满-1-螺环己烷。

  DOI：

  10.1016/s0031-9422(00)81194-2

文献信息

• TERPENE-BASED COMPOSITIONS, PROCESSES, METHODOLOGIES FOR CREATION AND PRODUCTS THEREBY
  申请人：The Werc Shop, LLC

  公开号：US20150080265A1

  公开（公告）日：2015-03-19

  Compositions which are fragrant and contain at least a member set culled from a library of compositions, each being comprised of sub-combinations of selected terpenes. Fragrances that mimic that of various states of organic and synthetic aromatics including products, processes and those from non-combusted plant products, among other things, uniquitous products, processes, medicinals, and related moieties leverage databases of all known terpene groupings are offered for consideration, and have been provided, according to the instant teachings.

  这段话的意思是：这些香味组合至少包含从香料库中挑选的一组成员，每个成员都由选定的萜烯亚组合组成。这些香味可以模仿各种有机和合成芳香化合物，包括产品、过程以及非燃烧植物产品等等，利用所有已知萜烯亚组合的数据库，提供了考虑的选择，并根据本文的教导提供了这些香味。
• Terpene-based compositions, processes methodologies
  申请人：The Werc Shop, LLC

  公开号：US10265292B2

  公开（公告）日：2019-04-23

  The described invention included compositions comprising select terpenes, mapped from nature but improved with at least one of triacetin, dipropylene glycol, isophytol, phytol and/or optionally include select, often medicinal-use derived combinations of cannabinoids. The compositions and devices have a variety of uses, such as for vaporization and inhalation, and for use as personal lubricants, and the like synthetic creations of which appear to mimic or improve upon natural phenomena, and while being highly inspired by the same, remain empirically and non-obviously distinct from the same.

  所述发明包括由精选的萜类化合物组成的组合物，这些萜类化合物来自自然界，但经过改进，至少含有三醋酸、二丙二醇、异植物醇、植物醇中的一种，并且/或者可选地包括精选的、通常是药用的大麻素组合。这些组合物和装置有多种用途，例如用于蒸发和吸入，以及用作个人润滑剂，以及类似的合成物，这些合成物似乎模仿或改进了自然现象，虽然受到自然现象的高度启发，但在经验上仍与自然现象有明显区别。
• Cannabinoid blends and formulations, related methods
  申请人：Scientific Holdings, LLC

  公开号：US10434084B2

  公开（公告）日：2019-10-08

  The disclosure provides methods for making homogeneous powders that are enriched in cannabinoids, and for blending the mixtures with pigments, emulsifiers, or odorants. The powders can be based on carbohydrates, sugars, cellulose-based polymers, or proteins.

  本公开提供了制作富含大麻素的均质粉末以及将混合物与颜料、乳化剂或气味剂混合的方法。这些粉末可以基于碳水化合物、糖、纤维素聚合物或蛋白质。
• Transparent glassy cannabinoid compositions
  申请人：SCIENTIFIC HOLDINGS, LLC

  公开号：US10654823B2

  公开（公告）日：2020-05-19

  The disclosure provides methods and compositions for providing shatter formulations taking the form of crystalline polymorphs, where methods of preparation include preparing tetrahydrocannabinol acid (THCA) powder followed by decarboxylating THCA and removal of terpenes.

  本公开提供了提供结晶多晶型粉碎制剂的方法和组合物，其中制备方法包括制备四氢大麻酚酸（THCA）粉末，然后对 THCA 进行脱羧处理并去除萜烯。
• Terpene-based compositions, processes, methodologies for creation and products thereby
  申请人：The Werc Shop, LLC

  公开号：US10774288B2

  公开（公告）日：2020-09-15

  Compositions which are fragrant and contain at least a member set culled from a library of compositions, each being comprised of sub-combinations of selected terpenes. Fragrances that mimic that of various states of organic and synthetic aromatics including products, processes and those from non-combusted plant products, among other things, uniquitous products, processes, medicinals, and related moieties leverage databases of all known terpene groupings are offered for consideration, and have been provided, according to the instant teachings.

  香味浓郁的组合物，至少包含从组合物库中挑选的一个成员集，每个成员集由选定萜烯的子组合组成。模仿各种有机和合成芳香剂状态的香味，包括产品、工艺和来自非燃烧植物产品的香味，其中包括独特的产品、工艺、药物和相关品种，根据本发明的教导，所有已知萜烯群的杠杆数据库都可供考虑并已提供。