3,5-Dihydroxydecanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3,5-Dihydroxydecanoic acid
• 化学式: C₁₀H₂₀O₄
• 分子量: 204.26
• InChiKey: WQZRAWSNEARGPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Methods and strains for producing bioproducts in Aureobasidium pullulans
  申请人：The United States of America, as represented by the Secretary of Agriculture

  公开号：US10351889B2

  公开（公告）日：2019-07-16

  The present disclosure provides methods for producing bioproducts from novel genetically altered strains of Aureobasidium pullulans. Methods and materials for the construction of these strains, examination of the bioproducts and analysis and isolation of the bioproducts from genetically altered strains is provided. Genetically altered A. pullulans strains in which one or more genes encoding biosynthetic enzymes are knocked out is detailed and the benefits of using such strains described.

  本公开提供了利用新型基因改变的 Aureobasidium pullulans 菌株生产生物产品的方法。提供了构建这些菌株、检查生物产品以及分析和分离来自基因改变菌株的生物产品的方法和材料。详细介绍了基因改变的 A. pullulans 菌株，其中一个或多个编码生物合成酶的基因被敲除，并说明了使用这种菌株的好处。
• Oils having antibacterial activity
  申请人：The United States of America, as Represented by the Secretary of Agriculture

  公开号：US10544085B2

  公开（公告）日：2020-01-28

  Compounds, called liamocins from Aureobasidium pullulans, having the general structure in Formula 1 are disclosed. where R1 is either COCH3 or H; and R2 is between two to ten O-linked 3,5-dihydroxydecanoate; and R3 can be a polyol (e.g., L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol (also called sorbitol), L- or D-galactitol (also called dulcitol), and L- or D-talitol), 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; except when R3 is D-mannitol, R2 is not 2 nor 3 O-linked 3,5-dihydroxydecanoate chains. These liamocins described above in addition to D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, and D-mannitol liamocin B2, alone or in combination with each other, can be used to kill certain bacteria and to treat certain bacterial infections.

  本研究公开了来自 Aureobasidium pullulans 的称为 liamocins 的化合物，其一般结构如式 1 所示。 其中，R1 是 COCH3 或 H；R2 是 2 至 10 个 O-连接的 3,5-二羟基癸酸酯；R3 可以是多元醇（例如、L-或 D-甘油、L-或 D-苏糖醇、L-或 D-赤藓糖醇、L-或 D-阿拉比托醇、L-或 D-木糖醇、L-或 D-来苏糖醇、L-或 D-核糖醇、L-或 D-阿立糖醇、L-或 D-阿立糖醇、L-或 D-甘露糖醇、L-或 D-iditol、L-或 D-谷糖醇、L-或 D-葡萄糖糖醇（又称山梨糖醇）、L-或 D-半乳糖醇（又称杜醇）和 L-或 D-塔糖醇）、2-氨基-D-甘露糖醇、2N-乙酰氨基-D-甘露糖醇、L-鼠李糖醇或 D-岩藻糖醇；除了当 R3 是 D-甘露糖醇时，R2 不是 2 个也不是 3 个 O-连接的 3,5-二羟基癸酸链。除了 D-甘露醇利阿莫西林 A1、D-甘露醇利阿莫西林 A2、D-甘露醇利阿莫西林 B1 和 D-甘露醇利阿莫西林 B2 之外，上述这些利阿莫西林可单独或相互组合用于杀灭某些细菌和治疗某些细菌感染。
• Aureobasidium pullulans strains with high-yield heavy oil and construction method and application thereof
  申请人：Tianjin University of Science and Technology

  公开号：US11352633B2

  公开（公告）日：2022-06-07

  An Aureobasidium pullulans recombinant strain with high-yield heavy oil and a construction method and application thereof are provided. The Aureobasidium pullulans recombinant strain is obtained by knocking out a pullulan synthetase PUL gene while overexpressing an ACL gene. The obtained Aureobasidium pullulans recombinant strain can significantly increase the yield of heavy oil. After 7-day fermentation with xylose as carbon source, the yield of the heavy oil of the recombinant strain reaches 19.4372 g/L, while the yield of the heavy oil of the original strain is 10.0325 g/L, i.e. the recombinant strain improves the yield by 93.74% compared with the original strain.

  本研究提供了一种具有高产重油的 Aureobasidium pullulans 重组菌株及其构建方法和应用。该 Aureobasidium pullulans 重组菌株是通过敲除拉普兰合成酶 PUL 基因，同时过表达 ACL 基因获得的。获得的 Aureobasidium pullulans 重组菌株可显著提高重油产量。以木糖为碳源发酵 7 天后，重组菌株的重油产量达到 19.4372 克/升，而原始菌株的重油产量为 10.0325 克/升，即重组菌株比原始菌株提高了 93.74%的产量。
• NOVEL BIOSURFACTANT PRODUCED BY AUREOBASIDIUM PULLULANS
  申请人：GYEONGBUK INSTITUTE FOR MARINE BIO-INDUSTRY

  公开号：US20140058122A1

  公开（公告）日：2014-02-27

  Disclosed is a novel compound having biosurfactant activity that is produced by Aureobasidium pullulans L-3-GPY strains (KCCM11200P). The novelty of the structure of the compound having biosurfactant activity was evaluated using spectroscopy, and it was determined that the biosurfactant produced by the strains has excellent surfactant activity. Active ingredients of the biosurfactant may be used for various purposes, for example, for producing a composition for washing and cleaning agents. Furthermore, they can be used in a variety of industrial fields where chemically synthesized surfactants are used such as medicines, foods, cosmetics, onshore and offshore oil decontamination, degradation of oil and fat in treatment tanks, and the like where chemically synthesized surfactants are used.
• NOVEL OILS HAVING ANTIBACTERIAL ACTIVITY
  申请人：THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE

  公开号：US20170050916A1

  公开（公告）日：2017-02-23

  Novel compounds, called liamocins from Aureobasidium pullulans , having the general structure in Formula 1 are disclosed. where R 1 is either COCH 3 or H; and R 2 is between two to ten O-linked 3,5-dihydroxydecanoate; and R 3 can be a polyol (e.g., L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol (also called sorbitol), L- or D-galactitol (also called dulcitol), and L- or D-talitol), 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; except when R 3 is D-mannitol, R 2 is not 2 nor 3 O-linked 3,5-dihydroxydecanoate chains. These liamocins described above in addition to D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, and D-mannitol liamocin B2, alone or in combination with each other, can be used to kill certain bacteria and to treat certain bacterial infections.