4-benzyloxy-3-methoxy-6-methyl-5,6-dihydro-benzo[4,5]imidazo[2,1-a]isoquinoline | 1390647-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-benzyloxy-3-methoxy-6-methyl-5,6-dihydro-benzo[4,5]imidazo[2,1-a]isoquinoline
• 英文别名: 3-Methoxy-6-methyl-4-phenylmethoxy-5,6-dihydrobenzimidazolo[2,1-a]isoquinoline；3-methoxy-6-methyl-4-phenylmethoxy-5,6-dihydrobenzimidazolo[2,1-a]isoquinoline
• CAS: 1390647-76-3
• 化学式: C₂₄H₂₂N₂O₂
• 分子量: 370.451
• InChiKey: NUOYPKLWFIJYCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  溴甲苯 在 二氯苯酚溴酯 、 lithium diisopropyl amide 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 4-benzyloxy-3-methoxy-6-methyl-5,6-dihydro-benzo[4,5]imidazo[2,1-a]isoquinoline
  参考文献：
  名称：

  Synthesis of dihydrobenzoimidazo[2,1-a]isoquinolines

  摘要：

  A one-pot protocol toward several substituted 5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinolines 1 starting with 2-allylbenzaldehydes 2 was described. The process was carried out the one-pot condensation/hydroamination reaction of substituted 2-allylbenzaldehydes 2 with 1,2-diaminobenzenes 3 in refluxing toluene in good yields. Skeleton 2 was prepared via one-pot ortho-metalative PhBCl2-mediated double alkylation of hydroxybenzaldehyde 4 with LDA in moderate yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.05.132

文献信息

• Synthesis of dihydrobenzoimidazo[2,1-a]isoquinolines
  作者：Meng-Yang Chang、Ming-Hao Wu、Yeh-Long Chen

  DOI：10.1016/j.tetlet.2012.05.132

  日期：2012.8

  A one-pot protocol toward several substituted 5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinolines 1 starting with 2-allylbenzaldehydes 2 was described. The process was carried out the one-pot condensation/hydroamination reaction of substituted 2-allylbenzaldehydes 2 with 1,2-diaminobenzenes 3 in refluxing toluene in good yields. Skeleton 2 was prepared via one-pot ortho-metalative PhBCl2-mediated double alkylation of hydroxybenzaldehyde 4 with LDA in moderate yields. (C) 2012 Elsevier Ltd. All rights reserved.