3-(4-methyl-furan-3-yl)-propan-1-ol | 118668-58-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 3-(4-methyl-furan-3-yl)-propan-1-ol
• 英文别名: 3-(4-methylfuran-3-yl)propan-1-ol
• CAS: 118668-58-9
• 化学式: C₈H₁₂O₂
• mdl: MFCD21339081
• 分子量: 140.182
• InChiKey: XSZRMRZQGPOROJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-methyl-furan-3-yl)-propan-1-ol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-(4-Methylfuran-3-yl)propanal
  参考文献：
  名称：

  阳极偶联反应：青蒿素环骨架的顺序环化途径。

  摘要：

  一对分子内阳极烯烃偶联反应已被用于构建青蒿素环骨架。两种偶联反应都利用呋喃环作为偶联伙伴之一。首先，发现由醛衍生的烯醇醚不是反应的有效引发基团。相反，环化从 N,O-烯酮缩醛起始基团的使用中受益匪浅。在第二次环化中，环内烯醇醚与呋喃环偶联。第二次电解反应在青蒿素环骨架的中心产生了关键的四取代碳。

  DOI：

  10.1021/ol702118n
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 在 偶氮二异丁腈 、 对甲苯磺酸 N-溴代丁二酰亚胺(NBS) 、 三丁基氯化锡 、 sodium cyanoborohydride 、 叔丁醇 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 3-(4-methyl-furan-3-yl)-propan-1-ol
  参考文献：
  名称：

  呋喃基自由基环化

  摘要：

  描述了一个三步的4-甲基呋喃环化序列，描述了溴缩醛自由基环化成2-烷氧基-4-亚甲基四氢呋喃的过程

  DOI：

  10.1016/s0040-4039(00)95629-6

文献信息

• SRIKRISHNA, A.;PULLAIAH, K. C., TETRAHEDRON LETT., 28,(1987) N 43, 5203-5204
  作者：SRIKRISHNA, A.、PULLAIAH, K. C.

  DOI：——

  日期：——
• 3-(4-Methylfuran-3-yl)propan-1-ol: A White-Spotted Stinkbug (Eysarcoris ventralis) Repellent Produced by an Endophyte Isolated from Green Foxtail
  作者：Hiromitsu Nakajima、Atsushi Ishihara、Yuji Sawa、Emi Sakuno

  DOI：10.1021/jf904093y

  日期：2010.3.10

  Stinkbug is a major rice plant pest in Asia. The extract of the culture filtrate of a fungus isolated from a green foxtail, Setaria viridis (L.) Beauv,, was found to have a repellent effect on the white-spotted stinkbug, Eysarcoris ventralis (Westwood). The active principle was purified and isolated, and identified as 3-(4-methylfuran-3-yl)propan-1-ol (1) on the basis of spectroscopic data. Four acyl derivatives were prepared from 1 and assessed for repellent effect on the stinkbug; the acetyl derivative 2 was most effective.
• ESSENTIAL OILS AND THEIR COMPOUNDS AS STINK BUG REPELLENTS
  申请人：Schneidmiller Rodney G.

  公开号：US20130104445A1

  公开（公告）日：2013-05-02

  Provided herein are essential oils and synthetic compounds, and combinations thereof, as repellent compositions for repelling insects, such as members of the Pentatomoidea superfamily, the Superfamily Coreoidea, and the family Miridae, commonly referred to as stink bugs/shield bugs, squash bugs and plant bugs, respectively. Controlled release devices comprising these repellent compositions are also provided. The repellent compositions may additionally be combined with attractant compositions in a type of “push-pull” method. The use of both repellents and attractants can increase the success rate for controlling stink bugs and the like.
• [EN] REMDESIVIR AND REMDESIVIR ANALOGS, SOLUTIONS, AND NANOPARTICLE, LIPOSOMAL, AND MICROPARTICLE COMPOSITIONS FOR TREATING VIRAL INFECTIONS<br/>[FR] REMDÉSIVIR ET ANALOGUES DE REMDÉSIVIR, SOLUTIONS ET COMPOSITIONS DE NANOPARTICULES, DE LIPOSOMES ET DE MICROPARTICULES POUR LE TRAITEMENT D'INFECTIONS VIRALES
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2021202907A2

  公开（公告）日：2021-10-07

  The present invention relates to methods, compounds, and compositions for treating viral infections, including COVID-19 viral infections. In certain embodiments, the compositions comprise: i) a remdesivir analog, ii) remdesivir or a remdesivir analog, and a surfactant, a cyclodextrin, or a combination thereof, iii) nanoparticles comprising albumin and remdesivir or remdesivir analog, iv) liposomes comprising lipids and remdesivir or remdesivir analog; and/or v) microparticles comprising PLA and/or PLGA, and remdesivir or remdesivir analog. In certain embodiments, the compositions are aqueous (e.g., for intravenous administration). In other embodiments, the compositions are nebulized or in the form of a dry powder (e.g., for inhalation by an infected subject).
• Anodic Coupling Reactions:  A Sequential Cyclization Route to the Arteannuin Ring Skeleton
  作者：Honghui Wu、Kevin D. Moeller

  DOI：10.1021/ol702118n

  日期：2007.10.1

  reactions has been used to construct the arteannuin ring skeleton. Both coupling reactions took advantage of a furan ring as one of the coupling partners. In the first, it was found that an enol ether derived from an aldehyde was not an effective initiating group for the reaction. Instead, the cyclization benefited strongly from the use of a N,O-ketene acetal initiating group. In the second cyclization

  一对分子内阳极烯烃偶联反应已被用于构建青蒿素环骨架。两种偶联反应都利用呋喃环作为偶联伙伴之一。首先，发现由醛衍生的烯醇醚不是反应的有效引发基团。相反，环化从 N,O-烯酮缩醛起始基团的使用中受益匪浅。在第二次环化中，环内烯醇醚与呋喃环偶联。第二次电解反应在青蒿素环骨架的中心产生了关键的四取代碳。