2-Methyl-1-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)propan-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-Methyl-1-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)propan-1-one
• 化学式: C₁₅H₁₈N₂O
• mdl: MFCD01820003
• 分子量: 242.32
• InChiKey: YAVXCXOFYMZNSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  36.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-B]INDOLE INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES<br/>[FR] 2,3,4,5-TÉTRAHYDRO-1H-PYRIDO[4,3-B]INDOLES INHIBITEURS DE CGAS UTILISÉS POUR LE TRAITEMENT DE MALADIES AUTO-INFLAMMATOIRES
  申请人：LAMA LODOE

  公开号：WO2019153002A1

  公开（公告）日：2019-08-08

  1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.

  本文披露了1-(3,4-二氢-1H-吡啶并[4,3-b]吲哚-2(5H)-基)-2-羟基乙酮。这些化合物是人类cGAS在产生干扰素的细胞类型中的抑制剂。因此，它们可用作治疗人类cGAS相关自身免疫疾病的治疗剂。
• 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-b]INDOLE INHIBITORS OF cGAS FOR TREATING AUTOINFLAMMATORY DISEASES
  申请人：The Rockefeller University

  公开号：US20210155625A1

  公开（公告）日：2021-05-27

  1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.